HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 36086954, 16537444
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, phosphatase assay
Interaction Type physical association, direct interaction, dephosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0030036 - actin cytoskeleton organization
GO:0030100 - regulation of endocytosis
GO:0032991 - protein-containing complex
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1130
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024