Protein: TOE1
Target of EGR1 protein 1

Gene: TOE1
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q96GM8

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0004535 - poly(A)-specific ribonuclease activity
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

472978

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

5

High-throughput

0.861

High

1137128

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

2

3

High-throughput

0.811

High

209319

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

1

High-throughput

0.691

High

471899

RU2B
U2 small nuclear ribonucleoprotein B''

1

3

High-throughput

0.691

High

478156

SNRPA
U1 small nuclear ribonucleoprotein A

1

5

High-throughput

0.691

High

1009285

PRR3
Proline-rich protein 3

1

1

High-throughput

0.691

High

1062079

SRSF4
Serine/arginine-rich splicing factor 4

1

4

High-throughput

0.691

High

1160245

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

4

High-throughput

0.691

High

1194282

LARP7
La-related protein 7

1

7

High-throughput

0.691

High

1392118

RBM19
Probable RNA-binding protein 19

1

6

High-throughput

0.691

High

974013

RUXF
Small nuclear ribonucleoprotein F

3

2

High-throughput

0.675

High

1037311

H11
Histone H1.1

3

5

High-throughput

0.667

High

485710

RU2A
U2 small nuclear ribonucleoprotein A'

4

0

High-throughput

0.661

High

913003

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

7

High-throughput

0.656

High

1099475

SRSF6
Serine/arginine-rich splicing factor 6

1

4

High-throughput

0.656

High

1127079

RBM39
RNA-binding protein 39

1

3

High-throughput

0.656

High

1392098

MEP50
Methylosome protein WDR77

1

2

High-throughput

0.656

High

1392120

RBM8A
RNA-binding protein 8A

1

4

High-throughput

0.656

High

372835

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.640

High

326836

SPN1
Snurportin-1

3

0

High-throughput

0.638

High

586826

RS2
Small ribosomal subunit protein uS5

3

0

High-throughput

0.638

High

574421

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

1

High-throughput

0.628

High

991224

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

1

High-throughput

0.628

High

1028693

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

High-throughput

0.622

High

1105373

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.622

High

1148003

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.622

High

1148759

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

5

High-throughput

0.618

High

302925

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

2

High-throughput

0.618

High

775256

FUS
RNA-binding protein FUS

1

6

High-throughput

0.618

High

1033147

EWS
RNA-binding protein EWS

1

2

High-throughput

0.618

High

1368859

RBP56
TATA-binding protein-associated factor 2N

1

2

High-throughput

0.618

High

1387484

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.618

High

1392093

TOE1
Target of EGR1 protein 1

1

3

High-throughput

0.618

High

1392103

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

5

High-throughput

0.618

High

974181

RUXG
Small nuclear ribonucleoprotein G

2

4

High-throughput

0.611

High

973793

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

1392102

WDR83
WD repeat domain-containing protein 83

1

1

High-throughput

0.587

High

401294

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.584

High

658338

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.576

High

521858

H14
Histone H1.4

2

5

High-throughput

0.574

High

649391

H1T
Histone H1t

2

5

High-throughput

0.574

High

396705

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

414404

P53
Cellular tumor antigen p53

1

2

Small-scale

0.568

High

1227249

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.553

High

907327

APLP1
Amyloid beta precursor like protein 1

1

2

High-throughput

0.541

High

991397

SUMO1
Small ubiquitin-related modifier 1

1

1

High-throughput

0.541

High

1392097

SH3G3
Endophilin-A3

1

2

High-throughput

0.541

High

290676

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

480267

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

488134

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

2

High-throughput

0.536

High

488188

IFIT1
Antiviral innate immune response effector IFIT1

1

2

High-throughput

0.536

High

595555

H15
Histone H1.5

1

5

High-throughput

0.536

High

809777

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

970038

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

974815

SMD3
Small nuclear ribonucleoprotein Sm D3

1

2

High-throughput

0.536

High

978656

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

984901

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

1006622

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.536

High

1112125

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.536

High

1392107

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.536

High

1392113

ZBT47
Zinc finger and BTB domain-containing protein 47

1

2

High-throughput

0.536

High

1392116

YBOX2
Y-box-binding protein 2

1

1

High-throughput

0.536

High

959906

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.518

High

422873

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

240157

FGF17
Fibroblast growth factor 17

1

0

High-throughput

0.513

High

257159

CCD22
Coiled-coil domain-containing protein 22

1

0

High-throughput

0.513

High

860314

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.513

High

860882

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

975861

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.513

High

1016161

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1113985

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1144907

RASA2
Ras GTPase-activating protein 2

1

0

High-throughput

0.513

High

1281438

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1291133

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1390573

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1392095

ZN668
Zinc finger protein 668

1

0

High-throughput

0.513

High

1392100

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

1392101

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.513

High

1392112

PIM2
Serine/threonine-protein kinase pim-2

1

0

High-throughput

0.513

High

1392115

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1324655

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

1

High-throughput

0.508

High

1392119

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

2

High-throughput

0.508

High

1392110

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.494

High

191746

MAGB2
Melanoma-associated antigen B2

1

3

High-throughput

0.489

High

502478

H2A1
Histone H2A type 1

1

2

High-throughput

0.489

High

595842

H13
Histone H1.3

1

5

High-throughput

0.489

High

967910

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.486

High

1095165

RED
Protein Red

1

0

High-throughput

0.486

High

1367734

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.486

High

185930

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

129325

MEN1
Menin

1

1

High-throughput

0.479

High

132230

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

242576

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

325984

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

Small-scale

0.479

High

346187

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

406501

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

487635

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

696205

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

768886

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

960207

RL26
Large ribosomal subunit protein uL24

1

1

High-throughput

0.479

High

1017112

H33
Histone H3.3

1

2

High-throughput

0.479

High

1024759

VIGLN
Vigilin

1

1

High-throughput

0.479

High

1045637

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1067598

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1137936

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1255053

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1334773

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1367011

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1368564

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

1392104

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1392106

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1392114

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

157729

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

335898

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

810282

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

879360

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

905027

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1100228

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1138507

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1155654

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1281585

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

1352684

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1392094

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1392099

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1392108

ANLN
Anillin

1

0

High-throughput

0.458

High

1392109

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1392111

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

259043

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.457

High

1108040

SQSTM
Sequestosome-1

1

2

High-throughput

0.457

High

1392117

SHLB1
Endophilin-B1

1

2

High-throughput

0.445

High

164823

UN13B
Protein unc-13 homolog B

1

0

High-throughput

0.438

High

220537

CAH12
Carbonic anhydrase 12

1

0

High-throughput

0.438

High

1392105

PININ
Pinin

1

0

High-throughput

0.438

High

504949

H2AB2
Histone H2A-Bbd type 2/3

1

3

High-throughput

0.437

High

970918

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1150791

SF01
Splicing factor 1

1

0

High-throughput

0.426

High

1209510

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1392096

RB40C
Ras-related protein Rab-40C

1

1

High-throughput

0.417

High

71602

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

4

High-throughput

0.407

High

402992

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

907684

CLCN2
Chloride channel protein 2

1

0

High-throughput

0.279

Low

1152836

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.279

Low

1260398

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.279

Low

962377

RHOA
Transforming protein RhoA

1

0

High-throughput

0.249

Low

1327132

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1338318

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

344767

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.238

Low

328108

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

1330788

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

1335676

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025