HitPredict

Interactor 1: ABL1 (P00520)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: SHIP1 (Q9ES52)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
Gene: Inpp5d

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	9393882, 11031258
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding GO:0043065 - positive regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1123 Mm			1 1191
+	Hs
		176332 ABL1_HUMAN (1-1123): 0: 925: 85.88		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Hs
		69199 A9UF07_HUMAN (25-1123): 0: 887: 85.30		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Mm
		403460 SRC_MOUSE (32-510): 1.48e-179: 537: 39.84		SHIP1_MOUSE (1-1191): 0: 930: 100.00
+	Hs
		166023 ABL1_HUMAN (1-1123): 0: 925: 85.88		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		433436 YES_HUMAN (5-510): 0: 542: 39.42		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		442867 HCK_HUMAN (9-508): 1.52e-173: 522: 38.60		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		433931 LYN_HUMAN (9-508): 1.69e-168: 508: 36.15		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		176351 LYN_HUMAN (9-508): 1.69e-168: 508: 36.15		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Hs
		166024 FYN_HUMAN (44-510): 5.28e-178: 534: 40.76		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		433324 YES_HUMAN (5-510): 0: 542: 39.42		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		522919 SRC_HUMAN (36-510): 0: 541: 39.96		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		412137 FYN_HUMAN (44-510): 5.28e-178: 534: 40.76		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		411678 LCK_HUMAN (9-508): 1.6e-174: 524: 38.49		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		243126 SRC_HUMAN (36-510): 0: 541: 39.96		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		155829 SRC_HUMAN (36-510): 0: 541: 39.96		SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33
+	Mm
		292397 FYN_MOUSE (44-510): 8.2e-178: 533: 40.76		SH21A_MOUSE (10-104): 1.81e-21: 93.2: 46.32
+	Hs
		243121 FYN_HUMAN (44-510): 5.28e-178: 534: 40.76		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		243120 LCK_HUMAN (9-508): 1.6e-174: 524: 38.49		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		243122 LYN_HUMAN (9-508): 1.69e-168: 508: 36.15		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		203198 LCK_HUMAN (9-508): 1.6e-174: 524: 38.49		SYNJ1_HUMAN (960-1191): 1.57e-11: 71.2: 13.62