HitPredict

Interactor 1: SRC64 (P00528)
Tyrosine-protein kinase Src64B (Dsrc64) (EC 2.7.10.2)
Gene: Src64B

Interactor 2: GRAP (Q08012)
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)
Gene: drk

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 552 Dm			1 211
+	Mm
		763393 FYN_MOUSE (31-549): 0: 551: 45.98		GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08
+	Hs
		412098 FYN_HUMAN (31-549): 0: 550: 45.79		VAV2_HUMAN (2-208): 7.42e-35: 132: 21.75
+	Hs
		412066 FYN_HUMAN (31-549): 0: 550: 45.79		CSK_HUMAN (2-136): 3.18e-25: 103: 36.30
+	Hs
		337307 FYN_HUMAN (31-549): 0: 550: 45.79		ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43
+	Hs
		412070 FYN_HUMAN (31-549): 0: 550: 45.79		ABL2_HUMAN (4-138): 3.23e-23: 98.6: 35.71
+	Hs
		337329 SRC_HUMAN (42-549): 0: 545: 49.41		ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43
+	Mm
		763403 FYN_MOUSE (31-549): 0: 551: 45.98		NCK1_MOUSE (5-143): 1.82e-20: 89.7: 32.35
+	Hs
		411986 FYN_HUMAN (31-549): 0: 550: 45.79		NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35
+	Hs
		411946 YES_HUMAN (5-549): 0: 565: 45.42		FYN_HUMAN (160-211): 2.56e-12: 66.9: 27.78
+	Hs
		433222 YES_HUMAN (5-549): 0: 565: 45.42		FGR_HUMAN (160-211): 3.92e-11: 63.5: 25.93
+	Hs
		433215 YES_HUMAN (5-549): 0: 565: 45.42		YES_HUMAN (160-211): 1.47e-10: 61.9: 25.93
+	Hs
		433216 YES_HUMAN (5-549): 0: 565: 45.42		LYN_HUMAN (97-211): 1.71e-10: 61.5: 17.09
+	Hs
		433231 YES_HUMAN (5-549): 0: 565: 45.42		SRC_HUMAN (160-211): 1.73e-10: 61.5: 25.93
+	Hs
		411981 FYN_HUMAN (31-549): 0: 550: 45.79		VAV_HUMAN (2-60): 7.85e-14: 71.6: 37.29
+	Hs
		412296 FYN_HUMAN (31-549): 0: 550: 45.79		SH3K1_HUMAN (3-60): 1.52e-13: 70.4: 27.12
+	Hs
		411936 FYN_HUMAN (31-549): 0: 550: 45.79		FYN_HUMAN (160-211): 2.56e-12: 66.9: 27.78
+	Hs
		411969 FYN_HUMAN (31-549): 0: 550: 45.79		SRC_HUMAN (160-211): 1.73e-10: 61.5: 25.93
+	Gg
		337663 SRC_CHICK (20-549): 0: 545: 48.04		SRC_CHICK (80-211): 1.14e-10: 61.9: 15.60
+	Mm
		403406 SRC_MOUSE (32-549): 0: 545: 48.66		SRC_MOUSE (160-211): 1.67e-10: 61.5: 25.93