Protein: ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

Gene: ISLR
Organism: Homo sapiens
Interactions: 145
UniProt ID: O14498

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0007155 - cell adhesion
GO:0031093 - platelet alpha granule lumen
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154784

RHBT3
Rho-related BTB domain-containing protein 3

3

9

High-throughput

0.861

High

154808

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

3

2

High-throughput

0.839

High

154807

NEK4
Serine/threonine-protein kinase Nek4

3

2

High-throughput

0.770

High

154885

LRC40
Leucine-rich repeat-containing protein 40

2

20

High-throughput

0.705

High

154777

LAMA5
Laminin subunit alpha-5

1

7

High-throughput

0.691

High

154787

NOE2
Noelin-2

1

7

High-throughput

0.691

High

154788

UROK
Urokinase-type plasminogen activator

1

9

High-throughput

0.691

High

154809

LAMB2
Laminin subunit beta-2

1

10

High-throughput

0.691

High

154819

SEM3B
Semaphorin-3B

1

1

High-throughput

0.691

High

154846

CILP2
Cartilage intermediate layer protein 2

1

7

High-throughput

0.691

High

154799

GALNS
N-acetylgalactosamine-6-sulfatase

3

3

High-throughput

0.667

High

154813

TBA4A
Tubulin alpha-4A chain

3

6

High-throughput

0.667

High

154826

TBB8
Tubulin beta-8 chain

3

4

High-throughput

0.667

High

154833

ARSK
Arylsulfatase K

3

3

High-throughput

0.667

High

154850

S11IP
Serine/threonine-protein kinase 11-interacting protein

3

20

High-throughput

0.650

High

154851

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

3

0

High-throughput

0.638

High

154915

TX264
Testis-expressed protein 264

3

0

High-throughput

0.638

High

154873

CNPY3
Protein canopy homolog 3

4

12

High-throughput

0.630

High

154828

GT253
Inactive glycosyltransferase 25 family member 3

2

1

High-throughput

0.628

High

154849

CNPY4
Protein canopy homolog 4

2

12

High-throughput

0.628

High

154783

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

15

High-throughput

0.618

High

154847

MIRO1
Mitochondrial Rho GTPase 1

1

9

High-throughput

0.618

High

154876

LRRC1
Leucine-rich repeat-containing protein 1

1

19

High-throughput

0.618

High

154892

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

2

High-throughput

0.618

High

154797

BMP7
Bone morphogenetic protein 7

1

1

High-throughput

0.618

High

154789

TBB4A
Tubulin beta-4A chain

2

4

High-throughput

0.611

High

154821

TBB3
Tubulin beta-3 chain

2

4

High-throughput

0.611

High

154838

TBA1A
Tubulin alpha-1A chain

2

6

High-throughput

0.611

High

154857

ELYS
Protein ELYS

2

1

High-throughput

0.611

High

154780

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

3

7

High-throughput

0.609

High

154793

ADT1
ADP/ATP translocase 1

3

4

High-throughput

0.609

High

154794

ADT3
ADP/ATP translocase 3

3

4

High-throughput

0.609

High

154827

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

3

2

High-throughput

0.609

High

154835

ZN562
Zinc finger protein 562

3

1

High-throughput

0.609

High

154837

CHSS3
Chondroitin sulfate synthase 3

3

4

High-throughput

0.609

High

154843

SETX
Probable helicase senataxin

3

1

High-throughput

0.609

High

154881

TM39B
Transmembrane protein 39B

3

1

High-throughput

0.609

High

154884

AT133
Polyamine-transporting ATPase 13A3

3

9

High-throughput

0.609

High

154896

RTEL1
Regulator of telomere elongation helicase 1

3

1

High-throughput

0.609

High

154910

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

3

1

High-throughput

0.609

High

154914

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

3

4

High-throughput

0.609

High

154863

LMLN
Leishmanolysin-like peptidase

2

0

High-throughput

0.602

High

154901

CATF
Cathepsin F

2

0

High-throughput

0.585

High

154814

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.579

High

154906

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

2

3

High-throughput

0.571

High

154875

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

18

High-throughput

0.553

High

133147

QSOX1
Sulfhydryl oxidase 1

1

1

High-throughput

0.536

High

154782

CRLF1
Cytokine receptor-like factor 1

1

9

High-throughput

0.536

High

154785

CSTN1
Calsyntenin-1

1

11

High-throughput

0.536

High

154791

BGLR
Beta-glucuronidase

1

1

High-throughput

0.536

High

154825

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.536

High

154832

GLB1L
Beta-galactosidase-1-like protein

1

2

High-throughput

0.536

High

154854

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

154878

TMM59
Transmembrane protein 59

1

2

High-throughput

0.536

High

154879

CNTP3
Contactin-associated protein-like 3

1

6

High-throughput

0.536

High

154904

PLXA1
Plexin-A1

1

3

High-throughput

0.536

High

154908

DD19B
ATP-dependent RNA helicase DDX19B

1

2

High-throughput

0.536

High

154795

ENPL
Endoplasmin

1

0

High-throughput

0.513

High

154800

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.513

High

154811

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.513

High

154812

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

154859

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

154864

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.513

High

76077

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

3

High-throughput

0.489

High

136571

MANBA
Beta-mannosidase

1

1

High-throughput

0.489

High

154790

ADT2
ADP/ATP translocase 2

1

4

High-throughput

0.489

High

154796

GDC
Solute carrier family 25 member 16

1

6

High-throughput

0.489

High

154803

MTOR
Serine/threonine-protein kinase mTOR

1

6

High-throughput

0.489

High

154805

GPC3
Glypican-3

1

4

High-throughput

0.489

High

154806

PLXA3
Plexin-A3

1

3

High-throughput

0.489

High

154810

SYJ2B
Synaptojanin-2-binding protein

1

18

High-throughput

0.489

High

154816

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.489

High

154820

OS9
Protein OS-9

1

1

High-throughput

0.489

High

154823

MBTP1
Membrane-bound transcription factor site-1 protease

1

1

High-throughput

0.489

High

154824

SYLM
Leucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.489

High

154830

TECT3
Tectonic-3

1

1

High-throughput

0.489

High

154831

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

3

High-throughput

0.489

High

154834

CREL2
Protein disulfide isomerase CRELD2

1

2

High-throughput

0.489

High

154841

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

3

High-throughput

0.489

High

154842

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

1

High-throughput

0.489

High

154844

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

3

High-throughput

0.489

High

154853

TTC13
Tetratricopeptide repeat protein 13

1

2

High-throughput

0.489

High

154856

RDH11
Retinol dehydrogenase 11

1

2

High-throughput

0.489

High

154860

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.489

High

154865

SFXN2
Sideroflexin-2

1

2

High-throughput

0.489

High

154869

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

154872

S2533
Solute carrier family 25 member 33

1

6

High-throughput

0.489

High

154877

SFXN3
Sideroflexin-3

1

2

High-throughput

0.489

High

154880

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

High-throughput

0.489

High

154883

SEM6B
Semaphorin-6B

1

1

High-throughput

0.489

High

154886

SFXN1
Sideroflexin-1

1

2

High-throughput

0.489

High

154889

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.489

High

154891

DJC11
DnaJ homolog subfamily C member 11

1

1

High-throughput

0.489

High

154893

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.489

High

154894

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

15

High-throughput

0.489

High

154898

CHPF2
Chondroitin sulfate glucuronyltransferase

1

2

High-throughput

0.489

High

154900

SE1L1
Protein sel-1 homolog 1

1

2

High-throughput

0.489

High

154907

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

5

High-throughput

0.489

High

154911

S27A6
Long-chain fatty acid transport protein 6

1

9

High-throughput

0.489

High

154913

ORNT1
Mitochondrial ornithine transporter 1

1

7

High-throughput

0.489

High

154792

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

154836

CD109
CD109 antigen

1

1

High-throughput

0.479

High

154817

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.458

High

154902

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.458

High

154798

S1PR1
Sphingosine 1-phosphate receptor 1

1

2

High-throughput

0.445

High

154840

CHST9
Carbohydrate sulfotransferase 9

1

1

High-throughput

0.445

High

154866

CNT3B
Contactin-associated protein-like 3B

1

7

High-throughput

0.445

High

154829

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

3

High-throughput

0.437

High

154855

S2540
Mitochondrial glutathione transporter SLC25A40

1

8

High-throughput

0.437

High

154858

TP4A1
Protein tyrosine phosphatase type IVA 1

1

4

High-throughput

0.437

High

154890

MDN1
Midasin

1

5

High-throughput

0.437

High

154897

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.437

High

154781

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.426

High

70002

D11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8

1

1

High-throughput

0.407

High

154801

TNR3
Tumor necrosis factor receptor superfamily member 3

1

4

High-throughput

0.407

High

154867

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

5

High-throughput

0.407

High

154895

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

3

High-throughput

0.407

High

154776

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

3

0

High-throughput

0.347

High

154779

XRCC3
DNA repair protein XRCC3

3

0

High-throughput

0.347

High

154786

SGPL1
Sphingosine-1-phosphate lyase 1

3

0

High-throughput

0.347

High

154815

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

3

0

High-throughput

0.347

High

154818

NTCP7
Sodium/bile acid cotransporter 7

3

0

High-throughput

0.347

High

154868

CDC6
Cell division control protein 6 homolog

3

0

High-throughput

0.347

High

154874

MTG1
Mitochondrial ribosome-associated GTPase 1

3

0

High-throughput

0.347

High

154912

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

3

0

High-throughput

0.347

High

154839

PGAP1
GPI inositol-deacylase

2

0

High-throughput

0.318

High

154802

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.279

Low

154822

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

0

High-throughput

0.279

Low

154845

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

154848

TRM2A
tRNA

1

0

High-throughput

0.279

Low

154852

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

154862

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.279

Low

154870

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.279

Low

154871

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

154882

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.279

Low

154887

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.279

Low

154888

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

154899

DHCR7
7-dehydrocholesterol reductase

1

0

High-throughput

0.279

Low

154903

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.279

Low

154905

METRN
Meteorin

1

0

High-throughput

0.279

Low

154916

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.279

Low

154804

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.249

Low

154861

INT4
Integrator complex subunit 4

1

0

High-throughput

0.249

Low

154778

B4GT5
Beta-1,4-galactosyltransferase 5

1

0

High-throughput

0.232

Low

154909

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025