HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: EGF (P01133)
Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)]
Gene: EGF

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 12093292, 25080504, 12297050, 12620237, 25453753, 26280537, 10085134, 36736316, 19531499, 18271526, 21822280, 10970856, 18427122, 11684674, 17697999, 8663535, 30083275, 9135143, 28988771, 2790960 and 1 others

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Identification Methods pull down, affinity chromatography technology, x-ray crystallography, transmission electron microscopy, surface plasmon resonance, 3D electron microscopy, molecular sieving, biochemical, x ray scattering, anti bait coimmunoprecipitation and 4 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EGF~Furin-like, EGF~Recep_L_domain
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0030297 - transmembrane receptor protein tyrosine kinase activator activity
and 9 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024