Protein: NFS1
Cysteine desulfurase (EC 2.8.1.7)

Gene: NFS1
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q9Y697

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

156518

ACPM
Acyl carrier protein, mitochondrial

4

3

High-throughput

0.895

High

1439634

LYRM4
LYR motif-containing protein 4

3

2

Small-scale

0.870

High

1431152

ISCU
Iron-sulfur cluster assembly enzyme ISCU

2

7

Small-scale

0.806

High

484698

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

1

High-throughput

0.667

High

1436159

ACAD9
Complex I assembly factor ACAD9, mitochondrial

3

1

High-throughput

0.667

High

1159367

FRDA
Frataxin, mitochondrial

1

4

Small-scale

0.647

High

1162646

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

1

Small-scale

0.640

High

330003

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

3

0

High-throughput

0.638

High

1448412

PICK1
PRKCA-binding protein

3

0

High-throughput

0.638

High

1199775

KLH22
Kelch-like protein 22

3

0

High-throughput

0.634

High

1388327

RRFM
Ribosome-recycling factor, mitochondrial

3

0

High-throughput

0.628

High

1491817

NFS1
Cysteine desulfurase

1

9

High-throughput

0.618

High

1310570

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.585

High

243442

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

279997

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

538186

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.576

High

409630

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

2

1

High-throughput

0.558

High

766134

PCGF2
Polycomb group RING finger protein 2

1

1

High-throughput

0.536

High

1243887

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

High-throughput

0.536

High

1250702

BCOR
BCL-6 corepressor

1

2

High-throughput

0.536

High

1432266

CLC4M
C-type lectin domain family 4 member M

1

1

High-throughput

0.536

High

1491818

TACC3
Transforming acidic coiled-coil-containing protein 3

1

1

High-throughput

0.536

High

274826

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

349719

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.513

High

361392

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

1006885

PHC1
Polyhomeotic-like protein 1

1

0

High-throughput

0.513

High

1104710

IKZF1
DNA-binding protein Ikaros

1

0

High-throughput

0.513

High

1335123

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1358009

EFMT1
EEF1A lysine methyltransferase 1

1

0

High-throughput

0.513

High

1449848

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1460881

FBX2
F-box only protein 2

1

0

High-throughput

0.513

High

1491412

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.513

High

1491819

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.513

High

1491753

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

129604

MEN1
Menin

1

1

High-throughput

0.479

High

282143

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287423

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

348819

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.479

High

361676

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

362429

ABL1
Tyrosine-protein kinase ABL1

1

2

High-throughput

0.479

High

397339

ESR1
Estrogen receptor

1

3

High-throughput

0.479

High

440810

FYN
Tyrosine-protein kinase Fyn

1

3

High-throughput

0.479

High

533113

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

786318

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

856446

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

882974

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

942988

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

988073

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.479

High

1015949

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1062872

QOR
Quinone oxidoreductase

1

2

High-throughput

0.479

High

1067891

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1083813

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1090606

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

1117895

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1240372

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

1256303

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1273051

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

1381153

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

1381796

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

1386067

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1396075

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.479

High

1401674

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1403491

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1413051

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.479

High

1416597

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

1432662

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1433771

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1434365

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1449944

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.479

High

1452876

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

1453075

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1453380

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

1459187

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1459490

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1462756

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

50877

NDUF8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

1

0

High-throughput

0.458

High

61702

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66350

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

137856

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

183786

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

194416

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

275145

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

351059

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

471351

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519280

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

560143

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

829033

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

842057

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852095

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

1024254

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048779

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058386

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1087643

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1106769

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1114783

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1123499

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1142721

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1207194

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1234589

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1241376

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1324125

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

1371812

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

1384928

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1387779

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1388474

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1397794

TEX55
Testis-specific expressed protein 55

1

0

High-throughput

0.458

High

1400853

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1412496

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1414135

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1415726

TR61B
tRNA

1

0

High-throughput

0.458

High

1418027

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

0

High-throughput

0.458

High

1418955

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1420444

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1428786

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1428845

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

1432014

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1432344

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1435852

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1446294

NGRN
Neugrin

1

0

High-throughput

0.458

High

1450486

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1451282

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

1451373

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1453992

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1491152

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1491739

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

1292525

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

2

High-throughput

0.445

High

1352025

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.445

High

377803

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

1177

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

347442

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.426

High

1034551

TAGL
Transgelin

1

0

High-throughput

0.426

High

1434781

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.426

High

1402878

GPX7
Glutathione peroxidase 7

3

0

High-throughput

0.345

High

1193510

CDNF
Cerebral dopamine neurotrophic factor

3

0

High-throughput

0.342

High

377021

NEU1
Oxytocin-neurophysin 1

1

0

High-throughput

0.279

Low

1158835

CART

1

0

High-throughput

0.279

Low

1314298

EFC13
EF-hand calcium-binding domain-containing protein 13

1

0

High-throughput

0.279

Low

1359286

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025