HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AREG (P15514)
Amphiregulin (AR) (Colorectum cell-derived growth factor) (CRDGF)
Gene: AREG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 0.60 0.667

The method score is based on:

Property Details
Experiments 10085134, 8663535, 28988771
Identification Methods pull down, affinity chromatography technology, biochemical, x ray scattering
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005789 - endoplasmic reticulum membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
and 4 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1210
Hs

1 252
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024