HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTPRB (P23467)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

Property	Details
Experiments	8870675, 28065597, 19167335, unassigned2173
Identification Methods	enzymatic study, two hybrid, phosphatase assay, ubiquitin reconstruction
Interaction Type	direct interaction, dephosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0043235 - receptor complex GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1997
+	Hs
		383611 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRB_HUMAN (1-1997): 0: 1320: 100.00
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (902-1709): 1.7e-69: 262: 12.33
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (1-619): 2.64e-62: 236: 16.59
+	Hs
		383597 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (1683-1964): 1.22e-49: 191: 35.37
+	Hs
		337733 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FINC_HUMAN (1147-1761): 1.77e-33: 144: 15.13
+	Hs
		337952 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENA_HUMAN (7-305): 1.63e-33: 144: 16.94
+	Hs
		1071017 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRH_HUMAN (1-619): 2.64e-62: 236: 16.59
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (530-955): 6.17e-17: 90.1: 11.37
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (903-1102): 2.88e-09: 65: 11.52
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (1703-1976): 7.13e-23: 109: 30.96
+	Hs
		383545 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (530-955): 6.17e-17: 90.1: 11.37
+	Hs
		146920 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRT_HUMAN (530-955): 6.17e-17: 90.1: 11.37