Protein: AGRL2
Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)

Gene: AGRL2, ADGRL2
Organism: Homo sapiens
Interactions: 110
UniProt ID: O95490

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338661

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

13

High-throughput

0.811

High

338635

TM11B
Transmembrane protease serine 11B

2

4

High-throughput

0.628

High

338573

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.618

High

338607

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.618

High

338623

NTRK2
BDNF/NT-3 growth factors receptor

1

7

High-throughput

0.618

High

338605

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

338667

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

5

Small-scale

0.541

High

338586

CALX
Calnexin

1

11

High-throughput

0.536

High

338642

S15A4
Solute carrier family 15 member 4

1

3

Small-scale

0.536

High

338628

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.514

High

338654

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.513

High

338616

IRF3
Interferon regulatory factor 3

1

1

High-throughput

0.489

High

338652

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.489

High

338584

CD9
CD9 antigen

1

13

High-throughput

0.484

High

338581

NCK1
SH2/SH3 adapter protein NCK1

1

7

High-throughput

0.481

High

126420

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

338620

EPHA7
Ephrin type-A receptor 7

1

7

High-throughput

0.479

High

338621

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

189364

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

225900

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

338570

DIRA3
GTP-binding protein Di-Ras3

1

2

High-throughput

0.479

High

338571

RASK
GTPase KRas

1

9

High-throughput

0.479

High

338572

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

338574

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

338575

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.479

High

338578

KCRB
Creatine kinase B-type

1

2

High-throughput

0.479

High

338579

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

338580

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

338582

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

338583

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.479

High

338587

EPHA2
Ephrin type-A receptor 2

1

8

High-throughput

0.479

High

338588

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

338592

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

338593

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

338594

EPHA4
Ephrin type-A receptor 4

1

10

High-throughput

0.479

High

338595

AFAD
Afadin

1

10

High-throughput

0.479

High

338596

ARL4C
ADP-ribosylation factor-like protein 4C

1

2

High-throughput

0.479

High

338597

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

338598

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

338599

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

338601

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

338602

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

338606

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

338608

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

338612

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

338624

OCLN
Occludin

1

1

High-throughput

0.479

High

338630

STYK1
Tyrosine-protein kinase STYK1

1

13

High-throughput

0.479

High

338634

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

338637

MIB1
E3 ubiquitin-protein ligase MIB1

1

1

High-throughput

0.479

High

338641

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.479

High

338644

PARD3
Partitioning defective 3 homolog

1

14

High-throughput

0.479

High

338646

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

338655

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

338656

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

338657

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

338658

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

338662

TM216
Transmembrane protein 216

1

1

High-throughput

0.479

High

338663

DNJ5B
DnaJ homolog subfamily C member 5B

1

1

High-throughput

0.479

High

338665

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.479

High

299004

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

327131

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

338577

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

338585

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

338604

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

338609

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

338613

CLN3
Battenin

1

0

Small-scale

0.458

High

338618

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

338625

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.458

High

338629

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

338633

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

338651

BRD8
Bromodomain-containing protein 8

1

0

High-throughput

0.458

High

338610

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

254702

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.445

High

255950

S19A2
Thiamine transporter 1

1

2

High-throughput

0.445

High

338576

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

1

High-throughput

0.445

High

338590

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

4

High-throughput

0.445

High

338591

S6A12
Sodium- and chloride-dependent betaine transporter

1

4

High-throughput

0.445

High

338603

TSN5
Tetraspanin-5

1

13

High-throughput

0.445

High

338615

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

338617

S39AE
Metal cation symporter ZIP14

1

10

High-throughput

0.445

High

338622

S15A2
Solute carrier family 15 member 2

1

3

High-throughput

0.445

High

338631

MFSD5
Molybdate-anion transporter

1

4

High-throughput

0.445

High

338632

S39A4
Zinc transporter ZIP4

1

10

High-throughput

0.445

High

338638

S35F2
Solute carrier family 35 member F2

1

7

High-throughput

0.445

High

338640

S35F3
Solute carrier family 35 member F3

1

2

High-throughput

0.445

High

338645

S35F5
Solute carrier family 35 member F5

1

7

High-throughput

0.445

High

338650

S39A8
Metal cation symporter ZIP8

1

10

High-throughput

0.445

High

338664

LAT2
Large neutral amino acids transporter small subunit 2

1

5

High-throughput

0.445

High

217300

PROM1
Prominin-1

1

0

Small-scale

0.438

High

174474

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.437

High

181674

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.437

High

338600

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.437

High

338614

CUL4A
Cullin-4A

1

3

High-throughput

0.437

High

338626

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.437

High

338653

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.437

High

338660

ARL15
ADP-ribosylation factor-like protein 15

1

2

High-throughput

0.437

High

338666

DJC16
DnaJ homolog subfamily C member 16

1

4

High-throughput

0.437

High

338611

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.426

High

219265

B4GA1
Beta-1,4-glucuronyltransferase 1

1

2

High-throughput

0.407

High

338627

S35F1
Solute carrier family 35 member F1

1

7

High-throughput

0.407

High

338639

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

338643

ZNT7
Zinc transporter 7

1

7

High-throughput

0.407

High

292985

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

338589

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

338619

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.249

Low

338636

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

338647

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

338649

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.249

Low

338659

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

338648

BSCL2
Seipin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025