Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 29880877, 33391517, 25402006, 24658140, 24189400, 16799092, unassigned2173, 15657067 |
| Identification Methods | affinity chromatography technology, two hybrid, protein complementation assay, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, ubiquitin reconstruction, tandem affinity purification |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | 14-3-3~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0019901 - protein kinase binding and 2 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
