Protein: SPTCS
Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein)

Gene: SPTCS, SPG11
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q96JI7

Gene Ontology (top 5):
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295233

AP5M1
AP-5 complex subunit mu-1

3

0

High-throughput

0.638

High

783714

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

0

High-throughput

0.602

High

1295255

CRYL1
Lambda-crystallin homolog

2

0

High-throughput

0.602

High

982382

1433F
14-3-3 protein eta

2

5

Small-scale

0.586

High

1295179

VCIP1
Deubiquitinating protein VCPIP1

2

0

Small-scale

0.580

High

983402

DYN1
Dynamin-1

2

0

Small-scale

0.566

High

1295227

DNJC7
DnaJ homolog subfamily C member 7

2

0

Small-scale

0.551

High

172181

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

599000

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.536

High

895711

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.536

High

1031052

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.536

High

1224635

ABI1
Abl interactor 1

1

1

High-throughput

0.536

High

1295243

ABI2
Abl interactor 2

1

2

High-throughput

0.536

High

200327

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.513

High

323967

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

335299

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

829130

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

High-throughput

0.513

High

1103410

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.513

High

1126950

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

1260584

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

1284762

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1290797

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.513

High

1295230

BBS2
Bardet-Biedl syndrome 2 protein

1

0

High-throughput

0.513

High

1295232

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1295242

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

1295245

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

1295249

SNX6
Sorting nexin-6

1

0

High-throughput

0.513

High

1295254

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

1295256

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.513

High

1295257

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

1295258

NPTN
Neuroplastin

1

0

High-throughput

0.513

High

1295259

WASF2
Actin-binding protein WASF2

1

0

High-throughput

0.513

High

647193

1433T
14-3-3 protein theta

1

5

Small-scale

0.501

High

683624

1433B
14-3-3 protein beta/alpha

1

5

Small-scale

0.501

High

904990

1433G
14-3-3 protein gamma

1

5

Small-scale

0.501

High

927408

1433Z
14-3-3 protein zeta/delta

1

5

Small-scale

0.501

High

1100120

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

909913

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.480

High

845171

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

845671

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

210203

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

295134

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

347602

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

527714

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.458

High

1152039

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1243888

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

224723

KALRN
Kalirin

1

2

Small-scale

0.457

High

253394

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

Small-scale

0.457

High

312644

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

Small-scale

0.457

High

365228

FRIH
Ferritin heavy chain

1

1

Small-scale

0.457

High

870871

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

Small-scale

0.457

High

963392

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

Small-scale

0.457

High

1022435

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

Small-scale

0.457

High

1045485

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

Small-scale

0.457

High

1066043

ARHG6
Rho guanine nucleotide exchange factor 6

1

1

Small-scale

0.457

High

1205891

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

1

2

Small-scale

0.457

High

1290025

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

Small-scale

0.457

High

64552

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

Small-scale

0.438

High

152494

ENC1
Ectoderm-neural cortex protein 1

1

0

Small-scale

0.438

High

257209

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

0

Small-scale

0.438

High

270695

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

Small-scale

0.438

High

334270

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.438

High

371462

FA11
Coagulation factor XI

1

0

Small-scale

0.438

High

375992

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.438

High

381274

TBB4A
Tubulin beta-4A chain

1

0

Small-scale

0.438

High

417756

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.438

High

422258

NFL
Neurofilament light polypeptide

1

0

Small-scale

0.438

High

500856

CLUS
Clusterin

1

0

Small-scale

0.438

High

526677

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

Small-scale

0.438

High

551051

CHIN
N-chimaerin

1

0

Small-scale

0.438

High

589232

ANXA7
Annexin A7

1

0

Small-scale

0.438

High

669447

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.438

High

777067

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

Small-scale

0.438

High

787388

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

0

Small-scale

0.438

High

788260

CASP2
Caspase-2

1

0

Small-scale

0.438

High

1019082

TP53B
TP53-binding protein 1

1

0

Small-scale

0.438

High

1027756

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.438

High

1030915

KCAB2
Voltage-gated potassium channel subunit beta-2

1

0

Small-scale

0.438

High

1051407

DCTN1
Dynactin subunit 1

1

0

Small-scale

0.438

High

1056616

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

Small-scale

0.438

High

1063032

MO4L2
Mortality factor 4-like protein 2

1

0

Small-scale

0.438

High

1068147

PDK2
[Pyruvate dehydrogenase

1

0

Small-scale

0.438

High

1083519

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

0

Small-scale

0.438

High

1129243

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

1

0

Small-scale

0.438

High

1133466

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

Small-scale

0.438

High

1151772

RGPA1
Ral GTPase-activating protein subunit alpha-1

1

0

Small-scale

0.438

High

1223957

CHSS2
Chondroitin sulfate synthase 2

1

0

Small-scale

0.438

High

1251396

TTC8
Tetratricopeptide repeat protein 8

1

0

Small-scale

0.438

High

1284419

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

Small-scale

0.438

High

1285997

MOAP1
Modulator of apoptosis 1

1

0

Small-scale

0.438

High

1295229

CSN4
COP9 signalosome complex subunit 4

1

0

Small-scale

0.438

High

1295234

GO45
Golgin-45

1

0

Small-scale

0.438

High

1295235

HIPK2
Homeodomain-interacting protein kinase 2

1

0

Small-scale

0.438

High

1295236

GOLP3
Golgi phosphoprotein 3

1

0

Small-scale

0.438

High

1295237

E41L1
Band 4.1-like protein 1

1

0

Small-scale

0.438

High

1295238

SYCM
Probable cysteine--tRNA ligase, mitochondrial

1

0

Small-scale

0.438

High

1295239

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

Small-scale

0.438

High

1295241

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

0

Small-scale

0.438

High

1295244

ATX10
Ataxin-10

1

0

Small-scale

0.438

High

1295248

FBX9
F-box only protein 9

1

0

Small-scale

0.438

High

1295250

EXOC7
Exocyst complex component 7

1

0

Small-scale

0.438

High

1295252

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

Small-scale

0.438

High

1295253

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.438

High

1219219

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

2

High-throughput

0.437

High

217926

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

596589

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

297087

TOM70
Mitochondrial import receptor subunit TOM70

1

1

Small-scale

0.417

High

1198244

DAAM2
Disheveled-associated activator of morphogenesis 2

1

1

Small-scale

0.417

High

1169888

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

1295226

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.318

High

1295247

SRTD3
SERTA domain-containing protein 3

1

0

High-throughput

0.299

High

263952

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

277269

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

1129897

DCA10
DDB1- and CUL4-associated factor 10

1

0

High-throughput

0.279

Low

1232951

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1262274

SPRY4
SPRY domain-containing protein 4

1

0

High-throughput

0.279

Low

1289625

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

1295228

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

258507

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

Small-scale

0.238

Low

269109

ZN821
Zinc finger protein 821

1

0

Small-scale

0.238

Low

1023534

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

0

Small-scale

0.238

Low

1054977

SPRL1
SPARC-like protein 1

1

0

Small-scale

0.238

Low

1058871

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

Small-scale

0.238

Low

1136011

FRY
Protein furry homolog

1

0

Small-scale

0.238

Low

1183880

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

Small-scale

0.238

Low

1232466

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

Small-scale

0.238

Low

1236019

EID2
EP300-interacting inhibitor of differentiation 2

1

0

Small-scale

0.238

Low

1281224

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

Small-scale

0.238

Low

1295225

EP400
E1A-binding protein p400

1

0

Small-scale

0.238

Low

1295231

KDM5D
Lysine-specific demethylase 5D

1

0

Small-scale

0.238

Low

1295240

ZHANG
CREB/ATF bZIP transcription factor

1

0

Small-scale

0.238

Low

1295246

IF172
Intraflagellar transport protein 172 homolog

1

0

Small-scale

0.238

Low

1295251

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024