Protein: M3K11
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)

Gene: M3K11, MAP3K11
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q16584

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0004709 - MAP kinase kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1083525

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

9

Small-scale

0.834

High

153136

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

15

Small-scale

0.778

High

158484

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

Small-scale

0.771

High

167556

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

8

Small-scale

0.771

High

719505

MERL
Merlin

1

3

Small-scale

0.771

High

1083518

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

2

9

Small-scale

0.757

High

325752

LATS1
Serine/threonine-protein kinase LATS1

1

6

Small-scale

0.747

High

681874

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.747

High

1032911

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

11

Small-scale

0.724

High

1083509

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

18

Small-scale

0.724

High

1083513

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

9

Small-scale

0.724

High

894058

CDC42
Cell division control protein 42 homolog

4

16

Small-scale

0.677

High

835385

GSK3A
Glycogen synthase kinase-3 alpha

1

12

Small-scale

0.665

High

1018161

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

11

Small-scale

0.665

High

1083527

TRAF6
TNF receptor-associated factor 6

3

7

Small-scale

0.664

High

234524

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.663

High

800985

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

15

Small-scale

0.647

High

655388

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

Small-scale

0.625

High

1020371

EPS8
Epidermal growth factor receptor kinase substrate 8

1

18

High-throughput

0.621

High

835791

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.618

High

927089

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.618

High

942351

DLG4
Disks large homolog 4

1

3

Small-scale

0.618

High

1083508

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

16

Small-scale

0.618

High

925309

RAC1
Ras-related C3 botulinum toxin substrate 1

2

16

Small-scale

0.586

High

431899

HS90A
Heat shock protein HSP 90-alpha

2

17

Small-scale

0.584

High

1020685

TRAF2
TNF receptor-associated factor 2

2

7

Small-scale

0.584

High

1083523

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

Small-scale

0.578

High

800789

MK08
Mitogen-activated protein kinase 8

1

15

Small-scale

0.575

High

1083517

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.541

High

394791

A4
Amyloid-beta precursor protein

1

1

Small-scale

0.501

High

951023

RHOG
Rho-related GTP-binding protein RhoG

1

16

Small-scale

0.501

High

1083524

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

3

Small-scale

0.501

High

166375

KIF3B
Kinesin-like protein KIF3B

1

7

Small-scale

0.481

High

1083516

KIFA3
Kinesin-associated protein 3

1

4

Small-scale

0.481

High

1083522

KIF17
Kinesin-like protein KIF17

1

7

Small-scale

0.481

High

1083526

KIF3A
Kinesin-like protein KIF3A

1

7

Small-scale

0.481

High

129565

TRAF5
TNF receptor-associated factor 5

1

7

Small-scale

0.479

High

438211

HS90B
Heat shock protein HSP 90-beta

1

17

Small-scale

0.479

High

545402

RAC2
Ras-related C3 botulinum toxin substrate 2

1

16

High-throughput

0.479

High

610420

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

714240

HSP74
Heat shock 70 kDa protein 4

1

2

Small-scale

0.479

High

740661

HPCL1
Hippocalcin-like protein 1

1

12

High-throughput

0.479

High

892395

RAC3
Ras-related C3 botulinum toxin substrate 3

1

14

High-throughput

0.479

High

901304

NCALD
Neurocalcin-delta

1

12

High-throughput

0.479

High

906763

NCS1
Neuronal calcium sensor 1

1

12

High-throughput

0.479

High

950452

HPCA
Neuron-specific calcium-binding protein hippocalcin

1

12

High-throughput

0.479

High

1022365

GRIK2
Glutamate receptor ionotropic, kainate 2

1

1

Small-scale

0.479

High

1082784

CDC37
Hsp90 co-chaperone Cdc37

1

4

Small-scale

0.479

High

1083512

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

1083514

RBCC1
RB1-inducible coiled-coil protein 1

1

3

High-throughput

0.479

High

1083520

TRIM5
Tripartite motif-containing protein 5

1

2

Small-scale

0.479

High

1037951

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.460

High

1083510

PLGT2
Protein O-glucosyltransferase 2

1

0

High-throughput

0.458

High

1083519

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

1083515

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

1083511

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.265

Low

1083521

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024