HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CTNA1 (P35221)
Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)
Gene: CTNNA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	24189400, 35384245, 37381005, 15657067
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0030054 - cell junction GO:0045296 - cadherin binding GO:0051015 - actin filament binding and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 906
+	Hs
		337959 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CTNA2_HUMAN (6-905): 0: 1044: 77.87
+	Hs
		383647 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CTNA1_HUMAN (1-906): 0: 1080: 100.00
+	Hs
		716635 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		CTNA1_HUMAN (1-906): 0: 1080: 100.00
+	Hs
		716687 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		CTNA1_HUMAN (1-906): 0: 1080: 100.00
+	Hs
		640712 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		CTNA2_HUMAN (6-905): 0: 1044: 77.87
+	Rn
		544858 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		Q5U302_RAT (1-906): 0: 1062: 99.23
+	Mm
		222844 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		CTNA2_MOUSE (6-905): 0: 1044: 77.77