Protein: ARHGB
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)

Gene: ARHGB, ARHGEF11
Organism: Homo sapiens
Interactions: 75
UniProt ID: O15085

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0001664 - G protein-coupled receptor binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177373

RHOA
Transforming protein RhoA

9

20

Small-scale

0.975

High

177372

CDC42
Cell division control protein 42 homolog

3

20

Small-scale

0.854

High

177408

ARHGC
Rho guanine nucleotide exchange factor 12

3

16

High-throughput

0.839

High

177380

GNA13
Guanine nucleotide-binding protein subunit alpha-13

3

20

Small-scale

0.827

High

177374

RHOB
Rho-related GTP-binding protein RhoB

3

20

Small-scale

0.821

High

177358

RHOC
Rho-related GTP-binding protein RhoC

2

20

High-throughput

0.811

High

177395

ARH40
Rho guanine nucleotide exchange factor 40

2

17

High-throughput

0.767

High

177402

PKH4B
Pleckstrin homology domain-containing family G member 4B

2

19

High-throughput

0.767

High

177387

MPRIP
Myosin phosphatase Rho-interacting protein

2

18

High-throughput

0.737

High

177403

NEB2
Neurabin-2

2

20

High-throughput

0.737

High

177360

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

7

Small-scale

0.713

High

177348

PLXB1
Plexin-B1

5

19

Small-scale

0.712

High

177352

PAK4
Serine/threonine-protein kinase PAK 4

4

9

High-throughput

0.694

High

177399

TRM61
tRNA

3

1

High-throughput

0.667

High

177414

PLXB3
Plexin-B3

3

19

Small-scale

0.648

High

175280

PLXB2
Plexin-B2

2

20

Small-scale

0.640

High

177411

PAK5
Serine/threonine-protein kinase PAK 5

2

13

High-throughput

0.628

High

177353

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

177356

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.618

High

177361

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

177362

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

High-throughput

0.618

High

177367

CRK
Adapter molecule crk

1

19

High-throughput

0.618

High

177370

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

Small-scale

0.618

High

177375

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

177376

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

177377

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

20

Small-scale

0.618

High

177388

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

177371

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.575

High

177350

MTX2
Metaxin-2

2

2

High-throughput

0.571

High

177354

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

177364

TMOD1
Tropomodulin-1

2

9

High-throughput

0.571

High

177385

WDR59
GATOR2 complex protein WDR59

2

17

High-throughput

0.571

High

177392

LONP2
Lon protease homolog 2, peroxisomal

2

1

High-throughput

0.571

High

177400

LRCH3
DISP complex protein LRCH3

2

1

High-throughput

0.571

High

177401

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

2

High-throughput

0.571

High

177404

S10AD
Protein S100-A13

2

3

High-throughput

0.571

High

177412

CING
Cingulin

2

6

High-throughput

0.571

High

177416

PPIE
Peptidyl-prolyl cis-trans isomerase E

2

7

High-throughput

0.571

High

177419

MYO5A
Unconventional myosin-Va

2

6

High-throughput

0.571

High

177384

MZT2B
Mitotic-spindle organizing protein 2B

2

0

High-throughput

0.547

High

177410

COMD9
COMM domain-containing protein 9

2

0

High-throughput

0.547

High

158380

RFXK
DNA-binding protein RFXANK

1

15

Small-scale

0.536

High

177366

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

177382

AINX
Alpha-internexin

2

17

High-throughput

0.521

High

177409

TMOD2
Tropomodulin-2

2

11

High-throughput

0.521

High

177405

F124B
Protein FAM124B

1

0

High-throughput

0.513

High

177365

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

177383

TIGD3
Tigger transposable element-derived protein 3

1

1

High-throughput

0.489

High

177417

KLH20
Kelch-like protein 20

1

3

Small-scale

0.481

High

177349

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

177351

ABCA1
Phospholipid-transporting ATPase ABCA1

1

2

Small-scale

0.479

High

177355

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

177357

PROF1
Profilin-1

1

5

High-throughput

0.479

High

177359

K1C19
Keratin, type I cytoskeletal 19

1

1

High-throughput

0.479

High

177363

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

High-throughput

0.479

High

177368

GSK3A
Glycogen synthase kinase-3 alpha

1

7

Small-scale

0.479

High

177369

GSK3B
Glycogen synthase kinase-3 beta

1

7

Small-scale

0.479

High

177379

TRDN
Triadin

1

7

High-throughput

0.479

High

177386

POTEE
POTE ankyrin domain family member E

1

15

High-throughput

0.479

High

177390

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

High-throughput

0.479

High

177391

HOOK3
Protein Hook homolog 3

1

14

High-throughput

0.479

High

177394

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

177397

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

177413

XPO7
Exportin-7

1

13

High-throughput

0.479

High

177415

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

177418

DAAM1
Disheveled-associated activator of morphogenesis 1

1

2

Small-scale

0.479

High

74395

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

10

High-throughput

0.470

High

177407

DISC1
Disrupted in schizophrenia 1 protein

1

8

High-throughput

0.457

High

177398

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.445

High

177378

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.437

High

177381

KS6A1
Ribosomal protein S6 kinase alpha-1

1

10

Small-scale

0.408

High

177393

NOA1
Nitric oxide-associated protein 1

2

0

High-throughput

0.298

High

177396

TFB1M
Dimethyladenosine transferase 1, mitochondrial

2

0

High-throughput

0.298

High

177406

DEFM
Peptide deformylase, mitochondrial

2

0

High-throughput

0.298

High

177389

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025