Protein: ABCA1
Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)

Gene: ABCA1
Organism: Homo sapiens
Interactions: 47
UniProt ID: O95477

Gene Ontology (top 5):
GO:0002790 - peptide secretion
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding
GO:0005548 - phospholipid transporter activity
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337988

APOA1
Apolipoprotein A-I

4

2

Small-scale

0.692

High

338013

ABCAC
Glucosylceramide transporter ABCA12

1

5

Small-scale

0.665

High

337999

NR1H2
Oxysterols receptor LXR-beta

3

3

Small-scale

0.633

High

338007

SNTB2
Beta-2-syntrophin

2

6

Small-scale

0.626

High

337991

CSK22
Casein kinase II subunit alpha'

1

0

Small-scale

0.614

High

184783

SPTC1
Serine palmitoyltransferase 1

2

1

Small-scale

0.594

High

337997

UTRN
Utrophin

2

2

Small-scale

0.584

High

338008

SNTB1
Beta-1-syntrophin

1

4

Small-scale

0.554

High

337995

CALX
Calnexin

1

2

Small-scale

0.536

High

338006

SNTA1
Alpha-1-syntrophin

1

8

Small-scale

0.536

High

338001

CDC42
Cell division control protein 42 homolog

1

1

Small-scale

0.534

High

338019

ERBIN
Erbin

1

0

Small-scale

0.505

High

338005

FADD
FAS-associated death domain protein

1

0

Small-scale

0.504

High

337989

DMD
Dystrophin

1

2

Small-scale

0.500

High

299003

FLOT1
Flotillin-1

1

0

Small-scale

0.493

High

338014

STX12
Syntaxin-12

1

0

Small-scale

0.493

High

338012

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

Small-scale

0.481

High

337992

FLNA
Filamin-A

1

0

Small-scale

0.479

High

337998

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.479

High

177351

ARHGB
Rho guanine nucleotide exchange factor 11

1

2

Small-scale

0.479

High

240380

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

299724

MPDZ
Multiple PDZ domain protein

1

3

Small-scale

0.479

High

337986

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

337987

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

338003

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

338010

DLG2
Disks large homolog 2

1

1

Small-scale

0.479

High

338016

DLG3
Disks large homolog 3

1

1

Small-scale

0.479

High

338017

CSN5
COP9 signalosome complex subunit 5

1

1

Small-scale

0.479

High

338020

LIN7B
Protein lin-7 homolog B

1

6

Small-scale

0.479

High

338022

ARHGC
Rho guanine nucleotide exchange factor 12

1

1

Small-scale

0.479

High

337993

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

Small-scale

0.460

High

337994

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.460

High

338023

ATX10
Ataxin-10

1

0

Small-scale

0.460

High

169369

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.458

High

338015

LNX1
E3 ubiquitin-protein ligase LNX

1

3

Small-scale

0.457

High

338021

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

254701

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

262355

DTNB
Dystrobrevin beta

1

2

Small-scale

0.445

High

338000

CD81
CD81 antigen

1

1

High-throughput

0.445

High

338009

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

338002

CSN2
COP9 signalosome complex subunit 2

2

0

Small-scale

0.305

High

338024

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.282

High

338018

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.279

Low

338004

AOXA
Aldehyde oxidase

1

0

Small-scale

0.251

Low

338011

UGPA
UTP--glucose-1-phosphate uridylyltransferase

1

0

Small-scale

0.251

Low

337990

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

337996

FUS
RNA-binding protein FUS

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025