HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTN7 (P35236)
Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP)
Gene: PTPN7

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0030054 - cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 360
+	Hs
		338456 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRR_HUMAN (6-358): 8.71e-139: 410: 53.52
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (14-358): 2.81e-121: 387: 31.64
+	Mm
		719299 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN11_MOUSE (3-358): 2.01e-118: 356: 29.37
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (82-355): 1.17e-116: 369: 35.71
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (65-359): 5.81e-118: 368: 30.80
+	Hs
		338317 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN11_HUMAN (3-358): 9.45e-119: 357: 29.37
+	Hs
		337987 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN6_HUMAN (80-356): 8.75e-116: 350: 34.46
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (93-354): 1.28e-105: 342: 36.06
+	Hs
		719339 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTN7_HUMAN (1-360): 1.34e-156: 445: 100.00
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (93-354): 6.22e-102: 331: 34.57
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (93-355): 1.23e-102: 321: 36.30
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (81-351): 1.21e-93: 295: 34.50
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (69-353): 6.02e-83: 276: 30.72
+	Hs
		665895 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTN6_HUMAN (80-356): 8.75e-116: 350: 34.46
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (93-354): 5.2e-61: 213: 27.37
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (86-353): 5.73e-61: 213: 26.07
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (92-357): 1.03e-58: 207: 25.81
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (71-360): 5.74e-56: 199: 23.76
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (93-354): 5.2e-61: 213: 27.37
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (73-358): 2.31e-55: 197: 24.83