HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: BMX (P51813)
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)
Gene: BMX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0032587 - ruffle membrane and 1 others more... GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 675
+	Hs
		338081 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TEC_HUMAN (1-674): 0: 675: 43.87
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (1-672): 0: 655: 43.70
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (145-668): 2.93e-171: 501: 30.61
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (145-668): 9.1e-172: 503: 30.74
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (132-668): 8.1e-171: 501: 28.42
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (145-668): 7.35e-170: 498: 30.74
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (132-669): 7.18e-166: 487: 29.95
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (133-674): 1.81e-164: 484: 28.99
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (132-669): 1.99e-162: 479: 29.71
+	Hs
		338082 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TXK_HUMAN (146-673): 3.03e-161: 475: 42.75
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (178-673): 2.31e-153: 474: 31.94
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (189-668): 6.8e-160: 471: 33.94
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (141-669): 2.18e-159: 470: 29.70
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (200-673): 1.14e-149: 465: 33.12
+	Hs
		338144 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLK_HUMAN (166-669): 9.46e-156: 460: 31.77
+	Hs
		412202 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		FYN_HUMAN (131-668): 7.58e-177: 516: 29.38
+	Hs
		433359 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		YES_HUMAN (132-668): 8.1e-171: 501: 28.42
+	Hs
		411729 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LCK_HUMAN (132-669): 7.18e-166: 487: 29.95
+	Hs
		337480 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ABL1_HUMAN (178-673): 2.31e-153: 474: 31.94
+	Hs
		433770 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LYN_HUMAN (141-669): 2.18e-159: 470: 29.70