HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030054 - cell junction GO:0045296 - cadherin binding GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1824
+	Hs
		665569 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		876391 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		338340 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KIF1A_HUMAN (183-586): 2.27e-62: 238: 15.40
+	Hs
		338448 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		339008 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		338350 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		1070968 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		DLG2_HUMAN (936-1143): 2.64e-33: 142: 24.55
+	Mm
		1142638 ERBB4_MOUSE (7-1199): 0: 1146: 49.53		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		942346 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51
+	Hs
		1070994 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25
+	Hs
		383736 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51
+	Hs
		434291 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		872713 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		665663 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		434182 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		665600 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		1049958 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		872638 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		665589 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		1020163 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14