HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 25402006, 24658140, 25754235, 18271526, unassigned2173, 16729043
Identification Methods two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0007165 - signal transduction
GO:0008284 - positive regulation of cell population proliferation
GO:0032991 - protein-containing complex
GO:0045296 - cadherin binding
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024