HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	20029029, unassigned2173
Identification Methods	protein complementation assay, ubiquitin reconstruction, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0031625 - ubiquitin protein ligase binding GO:0051117 - ATPase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 117
+	Hs
		338975 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74
+	Hs
		891156 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		383718 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		383970 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21
+	Hs
		601867 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		601995 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21
+	Mm
		724172 RET_MOUSE (420-1058): 5.27e-125: 414: 22.14		MLP3B_MOUSE (2-116): 2.53e-44: 141: 38.46
+	Hs
		1072594 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74