HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RB11A (P62491)
Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8)
Gene: RAB11A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37232246, 27569582
Identification Methods	proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0032991 - protein-containing complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 216
+	Hs
		338247 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB1A_HUMAN (1-213): 1.31e-90: 266: 44.60
+	Hs
		338205 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB25_HUMAN (2-190): 8.31e-87: 256: 67.20
+	Hs
		383971 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAB1B_HUMAN (4-213): 1.82e-87: 258: 46.19
+	Hs
		665197 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RB11A_HUMAN (1-216): 2.38e-94: 276: 100.00
+	Hs
		411350 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		RB11A_HUMAN (1-216): 2.38e-94: 276: 100.00
+	Hs
		665189 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RAB25_HUMAN (2-190): 8.31e-87: 256: 67.20
+	Rn
		544805 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		RB11A_RAT (1-216): 2.38e-94: 276: 100.00
+	Rn
		192819 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		RB11B_RAT (1-216): 2.54e-91: 268: 90.37
+	Rn
		102471 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		G3V6H0_RAT (4-213): 1.32e-86: 255: 46.19
+	Hs
		884475 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		RAB25_HUMAN (2-190): 8.31e-87: 256: 67.20
+	Hs
		435598 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		RB11A_HUMAN (1-216): 2.38e-94: 276: 100.00