Protein: G6PD
Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)

Gene: G6PD
Organism: Homo sapiens
Interactions: 109
UniProt ID: P11413

Gene Ontology (top 5):
GO:0004345 - glucose-6-phosphate dehydrogenase activity
GO:0005536 - D-glucose binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006006 - glucose metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

542738

G6PD
Glucose-6-phosphate 1-dehydrogenase

3

5

Small-scale

0.845

High

536381

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.585

High

240595

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

424627

KPCG
Protein kinase C gamma type

2

1

High-throughput

0.571

High

542762

KPCE
Protein kinase C epsilon type

2

1

High-throughput

0.571

High

542796

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.571

High

542806

SH3G3
Endophilin-A3

2

1

High-throughput

0.571

High

542808

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

530981

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.547

High

542743

VATB2
V-type proton ATPase subunit B, brain isoform

2

0

High-throughput

0.547

High

542759

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.547

High

542764

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

542817

SHOC2
Leucine-rich repeat protein SHOC-2

2

0

High-throughput

0.547

High

354513

PAK4
Serine/threonine-protein kinase PAK 4

1

0

Small-scale

0.537

High

542769

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

1

High-throughput

0.536

High

415305

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.515

High

192056

PA2GX
Group 10 secretory phospholipase A2

1

0

High-throughput

0.513

High

388960

FINC
Fibronectin

1

0

High-throughput

0.513

High

542746

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.513

High

542761

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.513

High

542777

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

542791

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

542797

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.513

High

542820

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

542792

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

0

Small-scale

0.493

High

542756

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

323133

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

395389

ESR1
Estrogen receptor

1

1

High-throughput

0.479

High

528172

THIO
Thioredoxin

1

2

Small-scale

0.479

High

542785

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

542790

MTMRD
Myotubularin-related protein 13

1

1

High-throughput

0.479

High

542793

DDX60
Probable ATP-dependent RNA helicase DDX60

1

1

High-throughput

0.479

High

542803

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

176130

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.458

High

345304

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

347495

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

377381

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

377934

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

399928

CATA
Catalase

1

0

High-throughput

0.458

High

411261

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

420322

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

542739

DMD
Dystrophin

1

0

High-throughput

0.458

High

542740

PLSL
Plastin-2

1

0

High-throughput

0.458

High

542748

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

542749

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

542750

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

542751

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

542752

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

542753

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

542754

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

542755

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

542757

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

542758

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

542760

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

542763

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

0

High-throughput

0.458

High

542765

PUR1
Amidophosphoribosyltransferase

1

0

High-throughput

0.458

High

542766

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

542767

TNK1
Non-receptor tyrosine-protein kinase TNK1

1

0

High-throughput

0.458

High

542768

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

542770

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.458

High

542771

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

542772

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

542773

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

542774

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

542775

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.458

High

542778

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

542780

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

542781

CDC73
Parafibromin

1

0

High-throughput

0.458

High

542783

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

542788

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

542795

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

542799

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

542800

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

542801

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

542802

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

542804

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.458

High

542809

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

542810

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

542812

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

542814

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

542815

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

542816

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.458

High

542745

GRN
Progranulin

1

1

High-throughput

0.445

High

542779

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

217762

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

542741

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

542747

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

528952

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

542807

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

High-throughput

0.328

High

542813

CAH10
Carbonic anhydrase-related protein 10

2

0

High-throughput

0.318

High

371028

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.305

High

542805

MYDGF
Myeloid-derived growth factor

2

0

High-throughput

0.305

High

542782

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.279

Low

542742

H12
Histone H1.2

1

0

High-throughput

0.269

Low

105206

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

259358

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

352895

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

542744

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

542776

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

542786

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

542787

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

542789

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

542794

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

542798

CC185
Coiled-coil domain-containing protein 185

1

0

High-throughput

0.249

Low

542811

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

542818

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

542784

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

542819

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025