Protein: 6PGL
6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)

Gene: 6PGL, PGLS
Organism: Homo sapiens
Interactions: 50
UniProt ID: O95336

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005975 - carbohydrate metabolic process
GO:0006098 - pentose-phosphate shunt
GO:0009051 - pentose-phosphate shunt, oxidative branch
GO:0017057 - 6-phosphogluconolactonase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

240367

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

333820

BLMH
Bleomycin hydrolase

2

0

High-throughput

0.580

High

333806

KRA59
Keratin-associated protein 5-9

1

4

High-throughput

0.481

High

333813

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.481

High

333814

KR108
Keratin-associated protein 10-8

1

3

High-throughput

0.481

High

333815

KR109
Keratin-associated protein 10-9

1

3

High-throughput

0.481

High

333822

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.481

High

333823

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.481

High

333835

KRA42
Keratin-associated protein 4-2

1

3

High-throughput

0.481

High

333809

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

333812

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

333821

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

333827

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

333831

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

333841

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

180458

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.460

High

333830

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

333832

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.460

High

333843

KLH20
Kelch-like protein 20

1

0

Small-scale

0.460

High

333802

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

333805

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

0

High-throughput

0.458

High

333810

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

333816

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

333826

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

333828

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

142260

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.445

High

333837

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

333842

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

333817

EWS
RNA-binding protein EWS

1

1

High-throughput

0.439

High

259249

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

333807

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

333808

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

333824

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

333836

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

330007

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

333804

ANFB
Natriuretic peptides B

1

1

High-throughput

0.407

High

333819

RM49
Large ribosomal subunit protein mL49

1

2

High-throughput

0.407

High

333834

MDFI
MyoD family inhibitor

2

0

High-throughput

0.330

High

333840

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.299

High

333811

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.288

High

333838

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

333825

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.251

Low

333801

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

333803

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

333818

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

333829

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

333839

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

333844

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

261029

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

333833

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025