HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.934

The method score is based on:

Property Details
Experiments 25402006, 24658140, 10806474, 20473329, unassigned2173, 15657067
Identification Methods two hybrid, protein complementation assay, affinity chromatography technology, anti bait coimmunoprecipitation, ubiquitin reconstruction
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_M~PK_Tyr_Ser-Thr, FERM_N_2~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0004713 - protein tyrosine kinase activity
GO:0005178 - integrin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 13 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

1 1052
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024