HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RHG01 (Q07960)
Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Gene: ARHGAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35384245, 24797263
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0010008 - endosome membrane GO:0045296 - cadherin binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 439
+	Hs
		64636 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Hs
		70637 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MYO9A_HUMAN (235-420): 3.51e-23: 105: 32.45
+	Hs
		383582 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CHIN_HUMAN (187-431): 1.89e-66: 221: 21.51
+	Hs
		601861 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		CHIO_HUMAN (187-431): 1.49e-64: 216: 21.91
+	Hs
		70640 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MYO9A_HUMAN (235-420): 3.51e-23: 105: 32.45
+	Hs
		411366 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Hs
		64660 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Rn
		88844 D3ZZK3_RAT (660-1016): 4.86e-120: 397: 31.25		CHIN_RAT (187-431): 2.29e-68: 222: 21.12
+	Mm
		975149 EPHA4_MOUSE (660-1016): 1.38e-120: 399: 31.52		CHIN_MOUSE (187-431): 2.63e-66: 220: 21.12
+	Hs
		64749 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Hs
		64659 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Rn
		88969 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D4A9G6_RAT (205-438): 5.91e-65: 227: 24.90
+	Hs
		435622 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Mm
		222853 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		RHG21_MOUSE (168-434): 1.23e-70: 244: 22.34
+	Mm
		222851 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		RHG23_MOUSE (179-438): 2.18e-65: 229: 24.81