Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: M3K12 (Q12852)
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
Gene: MAP3K12
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.68 | 1.00 | 0.825 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20029029, unassigned2173 |
| Identification Methods | protein complementation assay, affinity chromatography technology, ubiquitin reconstruction, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019901 - protein kinase binding and 3 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
