HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.80	0.775

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 533
+	Hs
		338635 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		1024132 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		338753 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Rn
		94037 Q9QX70_RAT (1-1210): 0: 1241: 90.34		F1LN91_RAT (103-512): 2.27e-33: 137: 12.39
+	Hs
		383773 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		338550 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		338552 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		339003 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		338683 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (174-447): 1.53e-11: 69.6: 10.64
+	Hs
		383868 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		1070974 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		1070975 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		1071015 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		383851 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		1070981 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		383853 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92