HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DSG2 (Q14126)
Desmoglein-2 (Cadherin family member 5) (HDGC)
Gene: DSG2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24797263, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0016324 - apical plasma membrane GO:0030054 - cell junction GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1118
+	Hs
		383799 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		337849 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Cl
		94520 ERBB2_CANLF (5-1200): 0: 1124: 48.54		CADH1_CANLF (30-670): 0: 572: 30.64
+	Hs
		383569 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		521720 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		872645 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		1048589 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		339196 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PCDB3_HUMAN (57-599): 1.32e-84: 293: 18.34
+	Hs
		337911 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		339197 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PCDBB_HUMAN (1-392): 8.44e-52: 198: 16.92
+	Hs
		338302 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		383600 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Xl
		292720 Q153D8_XENLA (10-1207): 0: 1055: 47.14		O93264_XENLA (1-493): 2.12e-78: 276: 18.63
+	Hs
		521744 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		434134 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		434321 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PCDGH_HUMAN (1-387): 8.41e-62: 230: 20.45
+	Hs
		580213 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		580236 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		872632 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		971014 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90