Protein: CXA8
Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70)

Gene: CXA8, GJA8
Organism: Homo sapiens
Interactions: 158
UniProt ID: P48165

Gene Ontology (top 5):
GO:0002088 - lens development in camera-type eye
GO:0005243 - gap junction channel activity
GO:0005886 - plasma membrane
GO:0005922 - connexin complex
GO:0007267 - cell-cell signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

706015

CXB2
Gap junction beta-2 protein

2

16

High-throughput

0.783

High

603883

CXA1
Gap junction alpha-1 protein

1

15

High-throughput

0.691

High

74156

SMIM1
Small integral membrane protein 1

2

1

High-throughput

0.606

High

141823

ACKR2
Atypical chemokine receptor 2

2

9

High-throughput

0.606

High

154471

CLD4
Claudin-4

2

1

High-throughput

0.606

High

155445

C2C2L
Phospholipid transfer protein C2CD2L

2

1

High-throughput

0.606

High

190200

MOT4
Monocarboxylate transporter 4

2

5

High-throughput

0.606

High

220361

LAT
Linker for activation of T-cells family member 1

2

2

High-throughput

0.606

High

328644

VAMP5
Vesicle-associated membrane protein 5

2

6

High-throughput

0.606

High

362209

ABL1
Tyrosine-protein kinase ABL1

2

11

High-throughput

0.606

High

539463

ITAM
Integrin alpha-M

2

3

High-throughput

0.606

High

622036

CD53
Leukocyte surface antigen CD53

2

5

High-throughput

0.606

High

850814

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

2

High-throughput

0.606

High

870702

BI1
Bax inhibitor 1

2

2

High-throughput

0.606

High

870703

AQP4
Aquaporin-4

2

4

High-throughput

0.606

High

870705

NAC3
Sodium/calcium exchanger 3

2

1

High-throughput

0.606

High

870707

STX1B
Syntaxin-1B

2

7

High-throughput

0.606

High

870711

PMP22
Peripheral myelin protein 22

2

2

High-throughput

0.606

High

870715

MALL
MAL-like protein

2

3

High-throughput

0.606

High

870716

S13A2
Solute carrier family 13 member 2

2

2

High-throughput

0.606

High

870717

SREC
Scavenger receptor class F member 1

2

1

High-throughput

0.606

High

870719

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

2

9

High-throughput

0.606

High

870724

TTMP
TPA-induced transmembrane protein

2

2

High-throughput

0.606

High

870726

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

6

High-throughput

0.606

High

870730

TMM65
Transmembrane protein 65

2

1

High-throughput

0.606

High

870735

MOT12
Monocarboxylate transporter 12

2

3

High-throughput

0.606

High

870736

MFSD6
Major facilitator superfamily domain-containing protein 6

2

1

High-throughput

0.606

High

870738

MOT13
Monocarboxylate transporter 13

2

5

High-throughput

0.606

High

870740

TSN33
Tetraspanin-33

2

6

High-throughput

0.606

High

870742

UN93A
Protein unc-93 homolog A

2

2

High-throughput

0.606

High

870744

S13A5
Na(+)/citrate cotransporter

2

2

High-throughput

0.606

High

870749

CLD19
Claudin-19

2

1

High-throughput

0.606

High

870752

CLC1A
C-type lectin domain family 1 member A

2

4

High-throughput

0.606

High

870753

PKR2
Prokineticin receptor 2

2

8

High-throughput

0.606

High

870754

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

6

High-throughput

0.606

High

870755

RL3R2
Relaxin-3 receptor 2

2

9

High-throughput

0.606

High

870756

GP151
G-protein coupled receptor 151

2

7

High-throughput

0.606

High

870762

S38A4
Sodium-coupled neutral amino acid transporter 4

2

8

High-throughput

0.606

High

870769

QRFPR
Pyroglutamylated RF-amide peptide receptor

2

6

High-throughput

0.606

High

870771

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

2

14

High-throughput

0.606

High

870774

P2Y13
P2Y purinoceptor 13

2

11

High-throughput

0.606

High

870780

GPR61
G-protein coupled receptor 61

2

5

High-throughput

0.606

High

870786

S1PR5
Sphingosine 1-phosphate receptor 5

2

10

High-throughput

0.606

High

870791

S39A2
Zinc transporter ZIP2

2

12

High-throughput

0.606

High

870796

S39A9
Zinc transporter ZIP9

2

12

High-throughput

0.606

High

870810

STX8
Syntaxin-8

2

6

High-throughput

0.606

High

561028

CCL4
C-C motif chemokine 4

2

0

High-throughput

0.580

High

870734

TM182
Transmembrane protein 182

2

0

High-throughput

0.580

High

870737

OTOP2
Proton channel OTOP2

2

0

High-throughput

0.580

High

870741

LAP4B
Lysosomal-associated transmembrane protein 4B

2

0

High-throughput

0.580

High

870770

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

2

0

High-throughput

0.580

High

870772

MGST2
Microsomal glutathione S-transferase 2

2

0

High-throughput

0.580

High

870779

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

870785

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.580

High

870797

TM100
Transmembrane protein 100

2

0

High-throughput

0.580

High

870800

S52A1
Solute carrier family 52, riboflavin transporter, member 1

2

0

High-throughput

0.580

High

870806

MARH2
E3 ubiquitin-protein ligase MARCHF2

2

0

High-throughput

0.580

High

870714

ZO1
Tight junction protein 1

1

20

Small-scale

0.561

High

122600

UBXN8
UBX domain-containing protein 8

2

5

High-throughput

0.553

High

231794

MFS11
UNC93-like protein MFSD11

2

2

High-throughput

0.553

High

257611

PRAF2
PRA1 family protein 2

2

3

High-throughput

0.553

High

280152

SC22B
Vesicle-trafficking protein SEC22b

2

9

High-throughput

0.553

High

295676

UPK1B
Uroplakin-1b

2

9

High-throughput

0.553

High

325527

YIF1A
Protein YIF1A

2

1

High-throughput

0.553

High

329623

LERL1
Leptin receptor overlapping transcript-like 1

2

2

High-throughput

0.553

High

331466

APOL3
Apolipoprotein L3

2

5

High-throughput

0.553

High

423751

APOD
Apolipoprotein D

2

1

High-throughput

0.553

High

636206

MAL
Myelin and lymphocyte protein

2

3

High-throughput

0.553

High

665958

IBP5
Insulin-like growth factor-binding protein 5

2

3

High-throughput

0.553

High

688377

PPLA
Phospholamban

2

1

High-throughput

0.553

High

870701

LIPR1
Inactive pancreatic lipase-related protein 1

2

1

High-throughput

0.553

High

870718

SC23A
Protein transport protein Sec23A

2

4

High-throughput

0.553

High

870720

CTXN3
Cortexin-3

2

2

High-throughput

0.553

High

870723

TM128
Transmembrane protein 128

2

2

High-throughput

0.553

High

870728

S35F1
Solute carrier family 35 member F1

2

3

High-throughput

0.553

High

870732

TM107
Transmembrane protein 107

2

1

High-throughput

0.553

High

870733

LAAT1
Lysosomal amino acid transporter 1 homolog

2

2

High-throughput

0.553

High

870739

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

3

High-throughput

0.553

High

870747

S35F6
Solute carrier family 35 member F6

2

4

High-throughput

0.553

High

870748

TM86B
Lysoplasmalogenase TMEM86B

2

5

High-throughput

0.553

High

870751

RN152
E3 ubiquitin-protein ligase RNF152

2

4

High-throughput

0.553

High

870758

GIMA1
GTPase IMAP family member 1

2

2

High-throughput

0.553

High

870759

S39A7
Zinc transporter SLC39A7

2

12

High-throughput

0.553

High

870764

YIPF6
Protein YIPF6

2

2

High-throughput

0.553

High

870765

GIMA5
GTPase IMAP family member 5

2

2

High-throughput

0.553

High

870766

S35A4
Probable UDP-sugar transporter protein SLC35A4

2

1

High-throughput

0.553

High

870767

RUSF1
RUS family member 1

2

1

High-throughput

0.553

High

870768

REEP6
Receptor expression-enhancing protein 6

2

1

High-throughput

0.553

High

870776

SC22C
Vesicle-trafficking protein SEC22c

2

9

High-throughput

0.553

High

870788

TMM60
Transmembrane protein 60

2

2

High-throughput

0.553

High

870792

GP108
Protein GPR108

2

3

High-throughput

0.553

High

870798

S38A7
Sodium-coupled neutral amino acid transporter 7

2

7

High-throughput

0.553

High

870807

PGAP2
Acyltransferase PGAP2

2

2

High-throughput

0.553

High

189452

STX7
Syntaxin-7

1

7

High-throughput

0.536

High

541394

FGFR1
Fibroblast growth factor receptor 1

1

9

High-throughput

0.536

High

870700

CTR2
Cationic amino acid transporter 2

1

7

High-throughput

0.536

High

870708

STXB1
Syntaxin-binding protein 1

1

9

High-throughput

0.536

High

870745

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

6

High-throughput

0.536

High

870773

S29A1
Equilibrative nucleoside transporter 1

1

3

High-throughput

0.536

High

870781

TTYH3
Protein tweety homolog 3

1

2

High-throughput

0.536

High

870793

GPC5C
G-protein coupled receptor family C group 5 member C

1

6

High-throughput

0.536

High

870804

GPC5B
G-protein coupled receptor family C group 5 member B

1

6

High-throughput

0.536

High

870731

OLFM4
Olfactomedin-4

1

2

High-throughput

0.515

High

870782

THS7B
Thrombospondin type-1 domain-containing protein 7B

1

4

High-throughput

0.515

High

333563

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.513

High

209750

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

1

High-throughput

0.489

High

397671

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

2

High-throughput

0.489

High

483888

HMOX1
Heme oxygenase 1

1

1

High-throughput

0.489

High

870713

PSME1
Proteasome activator complex subunit 1

1

3

High-throughput

0.489

High

870743

STX12
Syntaxin-12

1

7

High-throughput

0.489

High

870760

FAM3C
Protein FAM3C

1

3

High-throughput

0.489

High

870789

SNX25
Sorting nexin-25

1

3

High-throughput

0.489

High

870809

PSME2
Proteasome activator complex subunit 2

1

3

High-throughput

0.489

High

870812

MAN1
Inner nuclear membrane protein Man1

1

2

High-throughput

0.489

High

332911

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

5

High-throughput

0.481

High

870722

SGMR2
Sigma intracellular receptor 2

1

2

High-throughput

0.481

High

870803

NINJ2
Ninjurin-2

1

1

High-throughput

0.481

High

870763

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.480

High

870706

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.460

High

870787

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.460

High

870795

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

1

2

High-throughput

0.439

High

870783

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

Small-scale

0.437

High

49734

TMM72
Transmembrane protein 72

2

0

High-throughput

0.316

High

387514

APOA2
Apolipoprotein A-II

2

0

High-throughput

0.316

High

547985

PSPC
Surfactant protein C

2

0

High-throughput

0.316

High

789875

FDFT
Squalene synthase

2

0

High-throughput

0.316

High

870710

CP4F2
Cytochrome P450 4F2

2

0

High-throughput

0.316

High

870712

GUC2A
Guanylin

2

0

High-throughput

0.316

High

870721

ORML2
ORM1-like protein 2

2

0

High-throughput

0.316

High

870725

DB121
Beta-defensin 121

2

0

High-throughput

0.316

High

870727

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

2

0

High-throughput

0.316

High

870729

TMM42
Transmembrane protein 42

2

0

High-throughput

0.316

High

870746

S66A2
Solute carrier family 66 member 2

2

0

High-throughput

0.316

High

870750

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

2

0

High-throughput

0.316

High

870757

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

870775

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.316

High

870777

TM121
Transmembrane protein 121

2

0

High-throughput

0.316

High

870778

TM243
Transmembrane protein 243

2

0

High-throughput

0.316

High

870784

TWSG1
Twisted gastrulation protein homolog 1

2

0

High-throughput

0.316

High

870790

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

0

High-throughput

0.316

High

870794

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.316

High

870799

TM45A
Transmembrane protein 45A

2

0

High-throughput

0.316

High

870801

TM242
Transmembrane protein 242

2

0

High-throughput

0.316

High

870802

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

High-throughput

0.316

High

870805

CC167
Coiled-coil domain-containing protein 167

2

0

High-throughput

0.316

High

870811

DOLK
Dolichol kinase

2

0

High-throughput

0.316

High

870813

INSI2
Insulin-induced gene 2 protein

2

0

High-throughput

0.316

High

223607

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

223711

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.279

Low

326467

NDUB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

1

0

High-throughput

0.279

Low

328361

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.279

Low

870704

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.279

Low

870709

SELT
Thioredoxin reductase-like selenoprotein T

1

0

High-throughput

0.279

Low

870761

DNSL2
Deoxyribonuclease-1-like 2

1

0

High-throughput

0.279

Low

870808

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.279

Low

870814

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.279

Low

353093

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

830320

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025