HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: Q59G22 (Q59G22)
Fibronectin
Gene: Q59G22

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.80	0.653

Property	Details
Experiments	unassigned2173, 20029029
Identification Methods	ubiquitin reconstruction
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1011
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (89-924): 7.81e-103: 356: 12.65
+	Hs
		337733 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FINC_HUMAN (172-924): 4.18e-81: 292: 21.06
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (282-965): 9.78e-75: 272: 11.02
+	Hs
		337952 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENA_HUMAN (252-971): 3.26e-71: 261: 18.75
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (6-361): 1.35e-33: 142: 16.67
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (71-595): 4.29e-11: 69.7: 20.74
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (319-583): 2.33e-09: 64.1: 8.96
+	Hs
		1071017 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRH_HUMAN (6-361): 1.35e-33: 142: 16.67
+	Hs
		602004 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		PTPRH_HUMAN (6-361): 1.35e-33: 142: 16.67
+	Hs
		383611 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRB_HUMAN (71-595): 4.29e-11: 69.7: 20.74
+	Hs
		434120 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTPRF_HUMAN (89-924): 7.81e-103: 356: 12.65
+	Hs
		434315 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		FND3A_HUMAN (2-178): 1.91e-09: 64.1: 12.90
+	Hs
		983646 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		NEO1_HUMAN (185-990): 5.47e-78: 281: 11.80
+	Rn
		392799 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		FINC_RAT (700-936): 7.25e-16: 85.3: 12.70
+	Hs
		411297 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PTPRB_HUMAN (71-595): 4.29e-11: 69.7: 20.74
+	Hs
		411530 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		FND3A_HUMAN (2-178): 1.91e-09: 64.1: 12.90
+	Dm
		382202 EGFR_DROME (30-339): 1.78e-25: 116: 21.28		PTP10_DROME (11-499): 2.82e-09: 63.5: 21.92
+	Hs
		435806 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		FND3A_HUMAN (2-178): 1.91e-09: 64.1: 12.90