HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0032991 - protein-containing complex GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 351
+	Hs
		337799 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Rn
		948941 Q9QX70_RAT (1-1210): 0: 1241: 90.34		HS90A_RAT (1-350): 4.7e-174: 503: 84.40
+	Hs
		337788 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		337864 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		338519 EGFR_HUMAN (1-1210): 0: 1241: 100.00		H90B3_HUMAN (1-345): 2.38e-137: 404: 79.13
+	Hs
		438189 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431871 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Rn
		948940 Q8K3F9_RAT (5-1200): 0: 1129: 48.85		HS90A_RAT (1-350): 4.7e-174: 503: 84.40
+	Hs
		383544 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		383857 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		383537 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		437893 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431532 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		383576 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		431435 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438028 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431691 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438029 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431692 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		431561 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92