HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: TBA1A (Q71U36)
Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]
Gene: TUBA1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	25402006, 24658140, 16799092, unassigned2173, 15657067, 24189400
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, pull down, ubiquitin reconstruction, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 451
+	Hs
		338265 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBA4A_HUMAN (1-450): 0: 717: 96.00
+	Hs
		337782 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Hs
		338266 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB4B_HUMAN (1-437): 0: 693: 40.50
+	Hs
		601883 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBA4A_HUMAN (1-450): 0: 717: 96.00
+	Hs
		601882 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBA1B_HUMAN (1-440): 0: 715: 99.55
+	Hs
		428019 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Hs
		665575 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		TBA1B_HUMAN (1-440): 0: 715: 99.55
+	Hs
		933452 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBA4A_HUMAN (1-450): 0: 717: 96.00
+	Hs
		1072528 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		665203 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		TBA1B_HUMAN (1-440): 0: 715: 99.55
+	Hs
		428109 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Hs
		872631 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB4B_HUMAN (1-437): 0: 693: 40.50
+	Hs
		411416 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		428222 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Rn
		544865 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		TBA4A_RAT (1-450): 0: 717: 96.00
+	Hs
		411272 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Hs
		983628 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		796597 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Gg
		94429 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		TBB7_CHICK (1-439): 0: 695: 40.77
+	Hs
		428078 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		TBB5_HUMAN (1-439): 0: 695: 40.77