HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: FNBP1 (Q96RU3)
Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)
Gene: FNBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 617
+	Hs
		338992 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PPIP2_HUMAN (3-328): 3.23e-63: 213: 18.60
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (1-554): 3.3e-58: 211: 15.71
+	Hs
		338336 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FCHO2_HUMAN (3-579): 2.4e-52: 194: 14.75
+	Hs
		339132 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PACN2_HUMAN (179-607): 1.4e-23: 106: 11.26
+	Hs
		383980 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PPIP2_HUMAN (3-328): 3.23e-63: 213: 18.60
+	Hs
		383589 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FER_HUMAN (1-554): 3.3e-58: 211: 15.71
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (533-615): 2.01e-14: 79.1: 18.07
+	Hs
		561380 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		FER_HUMAN (1-554): 3.3e-58: 211: 15.71
+	Hs
		253317 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		SRGP2_HUMAN (6-510): 1.26e-55: 205: 14.36
+	Hs
		253355 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		SRGP2_HUMAN (6-510): 1.26e-55: 205: 14.36
+	Hs
		872636 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		FCHO2_HUMAN (3-579): 2.4e-52: 194: 14.75
+	Hs
		665588 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		FCHO2_HUMAN (3-579): 2.4e-52: 194: 14.75
+	Hs
		1001576 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		FCHO2_HUMAN (3-579): 2.4e-52: 194: 14.75
+	Hs
		789070 ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37		CIP4_HUMAN (1-611): 2.79e-95: 306: 49.84
+	Hs
		872730 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		PACN2_HUMAN (179-607): 1.4e-23: 106: 11.26
+	Hs
		665683 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PACN2_HUMAN (179-607): 1.4e-23: 106: 11.26
+	Hs
		1072628 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PACN2_HUMAN (179-607): 1.4e-23: 106: 11.26
+	Hs
		665608 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ITSN1_HUMAN (533-615): 2.01e-14: 79.1: 18.07
+	Mm
		222876 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		SRGP2_MOUSE (6-510): 7.08e-56: 206: 14.55
+	Hs
		435625 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		FCHO2_HUMAN (3-579): 2.4e-52: 194: 14.75