HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH23A (Q9BRG2)
SH2 domain-containing protein 3A (Novel SH2-containing protein 1)
Gene: SH2D3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	10187783, 25402006, 24658140, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid, protein complementation assay, ubiquitin reconstruction, luminescence based mammalian interactome mapping
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0033138 - positive regulation of peptidyl-serine phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 576
+	Hs
		275521 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BCAR3_HUMAN (8-574): 0: 570: 35.42
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (3-256): 8.05e-67: 228: 12.73
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (2-256): 7.01e-69: 233: 14.18
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (3-256): 8.44e-68: 231: 12.36
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (3-256): 7.28e-68: 231: 12.36
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (3-256): 5.43e-67: 228: 12.73
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (3-256): 5.16e-66: 225: 11.61
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (3-256): 5.43e-62: 215: 13.48
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (3-256): 1.89e-59: 207: 14.23
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (3-256): 8.1e-51: 190: 16.79
+	Hs
		338081 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TEC_HUMAN (3-228): 4.74e-49: 181: 14.75
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (3-166): 1.3e-44: 159: 18.64
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (3-166): 7.35e-45: 159: 19.21
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (1-118): 1.19e-31: 131: 32.00
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (7-114): 1.92e-36: 147: 31.48
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (2-254): 6.27e-34: 139: 18.42
+	Hs
		337779 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FES_HUMAN (3-114): 4.77e-32: 133: 34.82
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (1-118): 1.35e-32: 132: 31.20
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (3-149): 8.33e-34: 132: 29.94
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (1-117): 5.09e-32: 132: 32.26