Protein: KNL1
Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)

Gene: KNL1
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q8NG31

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0001669 - acrosomal vesicle
GO:0001675 - acrosome assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329950

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

9

1

Small-scale

0.975

High

224143

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

11

1

Small-scale

0.758

High

1339881

MIS12
Protein MIS12 homolog

8

1

Small-scale

0.750

High

786737

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

7

1

Small-scale

0.746

High

1334207

SPC24
Kinetochore protein Spc24

7

1

Small-scale

0.744

High

967859

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

6

1

Small-scale

0.737

High

251785

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

5

1

Small-scale

0.733

High

1339883

DSN1
Kinetochore-associated protein DSN1 homolog

9

0

Small-scale

0.721

High

1339871

NSL1
Kinetochore-associated protein NSL1 homolog

7

0

Small-scale

0.720

High

1339887

SPC25
Kinetochore protein Spc25

6

0

Small-scale

0.699

High

164020

NDC80
Kinetochore protein NDC80 homolog

5

0

Small-scale

0.689

High

1339879

NUF2
Kinetochore protein Nuf2

4

0

High-throughput

0.667

High

946170

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

1240753

PMF1
Polyamine-modulated factor 1

3

0

High-throughput

0.638

High

224328

BUB3
Mitotic checkpoint protein BUB3

2

2

High-throughput

0.628

High

1233768

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

717550

PDIA3
Protein disulfide-isomerase A3

2

0

High-throughput

0.576

High

372627

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

1339868

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.547

High

761774

HSP74
Heat shock 70 kDa protein 4

1

1

High-throughput

0.536

High

1094786

CAF1B
Chromatin assembly factor 1 subunit B

1

3

High-throughput

0.536

High

755602

TTK
Dual specificity protein kinase TTK

1

0

Small-scale

0.527

High

158473

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

347190

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

409000

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.513

High

682553

S100P
Protein S100-P

1

0

High-throughput

0.513

High

714281

PML
Protein PML

1

0

High-throughput

0.513

High

872551

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

1041777

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.513

High

1123047

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.513

High

1207237

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

1211265

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.513

High

1323676

K2C78
Keratin, type II cytoskeletal 78

1

0

High-throughput

0.513

High

1339866

KI18A
Kinesin-like protein KIF18A

1

0

High-throughput

0.513

High

1339872

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1339873

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.513

High

1339874

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

1339875

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

1339878

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1339880

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1339884

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1339892

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.513

High

1339893

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.513

High

1339897

POLH
DNA polymerase eta

1

0

High-throughput

0.513

High

155123

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.493

High

404243

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

1129661

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

520211

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

589207

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

984204

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

1048038

TLE3
Transducin-like enhancer protein 3

1

3

High-throughput

0.479

High

1086881

CDC20
Cell division cycle protein 20 homolog

1

4

Small-scale

0.479

High

1096759

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1097438

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.479

High

1158929

RBBP7
Histone-binding protein RBBP7

1

1

High-throughput

0.479

High

1227094

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1327567

WDTC1
WD and tetratricopeptide repeats protein 1

1

2

High-throughput

0.479

High

1338854

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

1339865

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

1339870

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

1339885

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.479

High

1339894

FBW1B
F-box/WD repeat-containing protein 11

1

1

High-throughput

0.479

High

138232

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

246781

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

247385

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

325936

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

414251

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

613404

VINC
Vinculin

1

0

High-throughput

0.458

High

695990

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768690

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

799314

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

887039

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

986581

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

991884

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

1109911

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1213454

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1244800

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1252900

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1272647

DET1
DET1 homolog

1

0

High-throughput

0.458

High

1276509

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1289466

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1313277

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1339867

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1339869

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

1339876

CENPO
Centromere protein O

1

0

Small-scale

0.458

High

1339882

HIPK2
Homeodomain-interacting protein kinase 2

1

0

High-throughput

0.458

High

1339888

NLE1
Notchless protein homolog 1

1

0

High-throughput

0.458

High

1339889

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1339890

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1339891

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.458

High

1339895

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1339898

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.458

High

117232

K7EJH0
Kinetochore protein Spc24

1

1

High-throughput

0.445

High

338911

CBX6
Chromobox protein homolog 6

1

1

High-throughput

0.445

High

1339877

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

2

High-throughput

0.445

High

302902

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

3

High-throughput

0.437

High

1339886

RC3H2
Roquin-2

1

1

High-throughput

0.437

High

537552

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

765724

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

1315527

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

0

High-throughput

0.426

High

1332279

GG6L2
Golgin subfamily A member 6-like protein 2

1

1

High-throughput

0.407

High

793728

ETFB
Electron transfer flavoprotein subunit beta

2

0

High-throughput

0.328

High

690046

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

712114

CO4A5

1

0

High-throughput

0.279

Low

878059

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.279

Low

1178852

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1219930

BSPRY
B box and SPRY domain-containing protein

1

0

High-throughput

0.279

Low

1331516

PRLD2
PRELI domain-containing protein 2

1

0

High-throughput

0.279

Low

1339896

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.269

Low

1025933

NDP
Norrin

1

0

Small-scale

0.249

Low

1241910

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1331530

CE120
Centrosomal protein of 120 kDa

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025