HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 2752
+	Hs
		338874 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MINT_HUMAN (709-2695): 5.55e-37: 157: 9.30
+	Hs
		338765 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC16_HUMAN (111-2747): 6.13e-36: 153: 10.09
+	Hs
		338965 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TARA_HUMAN (1540-2752): 1.5e-31: 138: 11.50
+	Hs
		338878 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC4_HUMAN (1029-2712): 5.23e-22: 107: 13.82
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		601846 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MAP1B_HUMAN (15-1517): 8.71e-69: 261: 10.13
+	Hs
		338292 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK2_HUMAN (1488-2676): 2.26e-09: 65.6: 13.23
+	Hs
		1071005 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC4_HUMAN (1029-2712): 5.23e-22: 107: 13.82
+	Hs
		383946 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC4_HUMAN (1029-2712): 5.23e-22: 107: 13.82
+	Hs
		601984 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC4_HUMAN (1029-2712): 5.23e-22: 107: 13.82
+	Hs
		983695 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Rn
		544878 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		SPEG_RAT (1479-2569): 1.56e-41: 171: 11.92
+	Hs
		311786 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		TACC2_HUMAN (1893-2744): 4.03e-13: 78.2: 8.34
+	Mm
		975153 EPHA4_MOUSE (660-1016): 1.38e-120: 399: 31.52		NCOR2_MOUSE (1288-2719): 2e-19: 99: 10.73
+	Hs
		665581 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK2_HUMAN (1488-2676): 2.26e-09: 65.6: 13.23
+	Mm
		222869 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		ANK2_MOUSE (875-2680): 3.07e-20: 101: 14.69