HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.805

Property	Details
Experiments	31585087, 19172738, 16253990
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 676
+	Hs
		338380 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		384030 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		383784 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		338561 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		338819 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOC10_HUMAN (7-457): 1.83e-53: 201: 11.79
+	Hs
		339001 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		338998 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		338640 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PHLB2_HUMAN (9-114): 2.45e-24: 111: 28.04
+	Hs
		339053 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLEK2_HUMAN (6-172): 2.31e-18: 89.3: 20.67
+	Hs
		602027 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DAPP1_HUMAN (9-125): 1.95e-26: 111: 27.27
+	Hs
		434188 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		724173 RET_MOUSE (420-1058): 5.27e-125: 414: 22.14		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		872642 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		665596 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		665234 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		872712 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		665662 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		1072603 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		665661 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		1072602 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35