Protein: TYDP2
Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase)

Gene: TYDP2, TDP2
Organism: Homo sapiens
Interactions: 72
UniProt ID: O95551

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003697 - single-stranded DNA binding
GO:0003714 - transcription corepressor activity
GO:0004518 - nuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

339147

SUMO3
Small ubiquitin-related modifier 3

2

2

Small-scale

0.800

High

339151

SUMO1
Small ubiquitin-related modifier 1

2

2

Small-scale

0.767

High

339149

SUMO2
Small ubiquitin-related modifier 2

1

2

Small-scale

0.680

High

171800

AZIN1
Antizyme inhibitor 1

3

0

High-throughput

0.638

High

339165

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.638

High

339132

ETS1
Protein C-ets-1

2

1

Small-scale

0.628

High

339148

JAM2
Junctional adhesion molecule B

1

1

High-throughput

0.625

High

339168

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

339129

P53
Cellular tumor antigen p53

2

1

High-throughput

0.584

High

339155

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.550

High

339175

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

339156

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.541

High

159447

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.536

High

339186

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.536

High

339130

RAP2A
Ras-related protein Rap-2a

1

2

High-throughput

0.536

High

249316

DLX3
Homeobox protein DLX-3

1

0

High-throughput

0.518

High

339142

PSN1
Presenilin-1

1

0

High-throughput

0.518

High

339146

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

339190

TRAF6
TNF receptor-associated factor 6

1

3

Small-scale

0.515

High

339145

ATX3
Ataxin-3

1

1

High-throughput

0.515

High

339173

SMIP5
Sperm-associated microtubule inner protein 5

1

0

High-throughput

0.513

High

339181

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

339182

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

339185

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.513

High

339187

RBX2
RING-box protein 2

1

0

High-throughput

0.513

High

339160

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.512

High

339133

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

2

Small-scale

0.504

High

339136

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

Small-scale

0.504

High

339143

DYN2
Dynamin-2

1

0

High-throughput

0.493

High

339131

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

339167

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.486

High

339152

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.481

High

136653

TRAF5
TNF receptor-associated factor 5

1

3

Small-scale

0.479

High

339125

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

339127

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

339137

TNR8
Tumor necrosis factor receptor superfamily member 8

1

2

Small-scale

0.479

High

339138

PML
Protein PML

1

2

High-throughput

0.479

High

339158

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

339162

TRAF2
TNF receptor-associated factor 2

1

3

Small-scale

0.479

High

339163

TRAF3
TNF receptor-associated factor 3

1

3

Small-scale

0.479

High

339164

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

339172

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

339126

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

Small-scale

0.460

High

339174

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.460

High

339128

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

339134

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

339135

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

339139

SOX6
Transcription factor SOX-6

1

0

High-throughput

0.458

High

339140

COIL
Coilin

1

0

High-throughput

0.458

High

339141

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

339153

H31
Histone H3.1

1

0

High-throughput

0.458

High

339154

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

339170

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

339171

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

339176

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

339177

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.458

High

339183

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

339178

AKAP9
A-kinase anchor protein 9

1

1

High-throughput

0.439

High

192048

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.328

High

339169

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

339179

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.328

High

339144

BLK
Tyrosine-protein kinase Blk

2

0

High-throughput

0.316

High

339188

CS025
UPF0449 protein C19orf25

2

0

High-throughput

0.313

High

339184

BTBD2
BTB/POZ domain-containing protein 2

1

0

High-throughput

0.292

High

339150

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.282

High

339157

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.282

High

339159

AT5G2
ATP synthase F(0) complex subunit C2, mitochondrial

1

0

High-throughput

0.282

High

339161

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.282

High

339180

SMAKA
Small membrane A-kinase anchor protein

1

0

High-throughput

0.282

High

339191

SNX13
Sorting nexin-13

1

0

High-throughput

0.282

High

339189

NINL
Ninein-like protein

1

0

High-throughput

0.249

Low

339166

EREP1
Endosomal transmembrane epsin interactor 1

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025