Interactor 1: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Interactor 2: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.866

The method score is based on:

Property Details
Experiments 18923394, 22405009, 21909074
Identification Methods comigration in non denaturing gel electrophoresis, x-ray crystallography, cross-linking study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Serpin~Serpin
Common GO terms GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
and 11 others

more...

Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 418
Hs

1 418
+ Hs
+ Hs
+ Hs
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024