HitPredict

Interactor 1: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Interactor 2: KLK1 (P06870)
Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)
Gene: KLK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	3643793
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 262
+	Hs
		344149 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK3_HUMAN (1-261): 6.64e-108: 314: 60.54
+	Hs
		344274 AACT_HUMAN (20-417): 3e-164: 469: 43.56		KLK2_HUMAN (1-261): 6.63e-115: 331: 65.90
+	Mm
		430527 A1AT1_MOUSE (1-418): 7.71e-163: 465: 63.48		Q9Z1R9_MOUSE (5-261): 3.31e-115: 332: 40.86
+	Hs
		344349 AACT_HUMAN (20-417): 3e-164: 469: 43.56		KLK13_HUMAN (1-260): 9.68e-106: 309: 40.07
+	Hs
		397636 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLK2_HUMAN (1-261): 6.63e-115: 331: 65.90
+	Hs
		344097 ANT3_HUMAN (17-418): 4.53e-142: 415: 28.40		KLK1_HUMAN (1-262): 8.56e-125: 357: 100.00
+	Hs
		420739 KAIN_HUMAN (45-417): 4.47e-139: 405: 45.14		KLK1_HUMAN (1-262): 8.56e-125: 357: 100.00
+	Hs
		397629 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLK3_HUMAN (1-261): 6.64e-108: 314: 60.54
+	Hs
		428671 SPB8_HUMAN (48-415): 1.46e-145: 420: 31.48		TRY1_HUMAN (5-262): 3.83e-115: 332: 40.31
+	Hs
		589593 SPB6_HUMAN (48-415): 1.4e-145: 420: 31.22		KLK2_HUMAN (1-261): 6.63e-115: 331: 65.90
+	Hs
		719387 SPB6_HUMAN (48-415): 1.4e-145: 420: 31.22		KLK13_HUMAN (1-260): 9.68e-106: 309: 40.07
+	Mm
		1141519 SPB6_MOUSE (48-415): 1.81e-147: 425: 30.42		KLK8_MOUSE (2-260): 5.89e-102: 299: 42.86
+	Hs
		371463 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLKB1_HUMAN (17-261): 4.48e-88: 275: 31.92
+	Hs
		714770 SPB12_HUMAN (48-415): 3.78e-135: 394: 28.47		TRY3_HUMAN (11-262): 5.74e-110: 320: 41.67
+	Hs
		344256 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK4_HUMAN (23-258): 1.09e-50: 168: 40.08
+	Hs
		198328 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK10_HUMAN (28-261): 4.36e-46: 157: 37.29
+	Hs
		198377 CBG_HUMAN (31-415): 1.84e-153: 441: 42.23		KLK10_HUMAN (28-261): 4.36e-46: 157: 37.29
+	Hs
		486155 SPB9_HUMAN (49-415): 1.97e-159: 455: 33.60		GRAB_HUMAN (25-258): 4e-37: 132: 36.52
+	Hs
		198417 SPB10_HUMAN (48-415): 6.2e-147: 424: 30.56		KLK10_HUMAN (28-261): 4.36e-46: 157: 37.29
+	Hs
		344100 ANT3_HUMAN (17-418): 4.53e-142: 415: 28.40		GRAA_HUMAN (24-258): 3.08e-37: 133: 35.92