HitPredict

Interactor 1: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Interactor 2: KLK4 (Q9Y5K2)
Kallikrein-4 (EC 3.4.21.-) (Enamel matrix serine proteinase 1) (Kallikrein-like protein 1) (KLK-L1) (Prostase) (Serine protease 17)
Gene: KLK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 254
+	Hs
		344148 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK1_HUMAN (9-254): 3.22e-103: 301: 38.78
+	Hs
		344149 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK3_HUMAN (8-254): 1.28e-101: 297: 37.31
+	Mm
		430527 A1AT1_MOUSE (1-418): 7.71e-163: 465: 63.48		Q9Z1R9_MOUSE (9-254): 3.41e-118: 339: 36.69
+	Hs
		344274 AACT_HUMAN (20-417): 3e-164: 469: 43.56		KLK2_HUMAN (8-254): 1.59e-105: 307: 38.08
+	Hs
		344349 AACT_HUMAN (20-417): 3e-164: 469: 43.56		KLK13_HUMAN (7-253): 1.53e-104: 305: 39.77
+	Hs
		397636 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLK2_HUMAN (8-254): 1.59e-105: 307: 38.08
+	Hs
		397629 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLK3_HUMAN (8-254): 1.28e-101: 297: 37.31
+	Hs
		371463 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLKB1_HUMAN (22-254): 5.69e-96: 295: 31.33
+	Mm
		1141519 SPB6_MOUSE (48-415): 1.81e-147: 425: 30.42		KLK8_MOUSE (1-251): 2.3e-105: 307: 39.92
+	Hs
		1218311 SPA12_HUMAN (1-418): 1e-153: 442: 38.28		TM11E_HUMAN (16-252): 1.2e-96: 290: 27.53
+	Mm
		936828 IPSP_MOUSE (52-415): 9.22e-149: 429: 42.23		TM11E_MOUSE (16-252): 2.6e-95: 287: 27.82
+	Hs
		198328 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK10_HUMAN (34-254): 5.79e-42: 145: 36.80
+	Hs
		344178 A1AT_HUMAN (1-418): 0: 521: 100.00		GRAM_HUMAN (15-254): 5.73e-41: 142: 36.36
+	Hs
		344283 AACT_HUMAN (20-417): 3e-164: 469: 43.56		GRAM_HUMAN (15-254): 5.73e-41: 142: 36.36
+	Hs
		344266 AACT_HUMAN (20-417): 3e-164: 469: 43.56		CATG_HUMAN (30-253): 6.71e-36: 129: 32.17
+	Hs
		839515 SPB9_HUMAN (49-415): 1.97e-159: 455: 33.60		GRAM_HUMAN (15-254): 5.73e-41: 142: 36.36
+	Hs
		198377 CBG_HUMAN (31-415): 1.84e-153: 441: 42.23		KLK10_HUMAN (34-254): 5.79e-42: 145: 36.80
+	Hs
		486155 SPB9_HUMAN (49-415): 1.97e-159: 455: 33.60		GRAB_HUMAN (30-252): 3.62e-36: 130: 32.61
+	Hs
		198417 SPB10_HUMAN (48-415): 6.2e-147: 424: 30.56		KLK10_HUMAN (34-254): 5.79e-42: 145: 36.80
+	Hs
		439323 SPB4_HUMAN (48-415): 1.16e-148: 428: 32.31		CATG_HUMAN (30-253): 6.71e-36: 129: 32.17