HitPredict

Interactor 1: AACT (P01011)
Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]
Gene: SERPINA3

Interactor 2: GRAM (P51124)
Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
Gene: GZMM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15494398
Identification Methods	comigration in sds page
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 257
+	Hs
		344349 AACT_HUMAN (1-423): 0: 526: 100.00		KLK13_HUMAN (28-255): 2.55e-99: 292: 34.89
+	Hs
		344178 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		GRAM_HUMAN (1-257): 1.22e-107: 313: 100.00
+	Mm
		430527 A1AT1_MOUSE (21-421): 1.3e-157: 452: 43.53		Q9Z1R9_MOUSE (5-256): 1.34e-108: 315: 32.17
+	Hs
		839515 SPB9_HUMAN (48-420): 3.52e-155: 445: 33.42		GRAM_HUMAN (1-257): 1.22e-107: 313: 100.00
+	Hs
		177775 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		TMPS2_HUMAN (5-257): 2.28e-98: 297: 27.69
+	Hs
		344148 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		KLK1_HUMAN (5-257): 8.51e-98: 288: 28.73
+	Hs
		371463 IPSP_HUMAN (51-420): 1.43e-152: 439: 49.46		KLKB1_HUMAN (17-256): 4.45e-99: 303: 30.40
+	Hs
		428671 SPB8_HUMAN (49-420): 2.07e-143: 415: 33.25		TRY1_HUMAN (5-257): 5.77e-109: 316: 31.27
+	Mm
		936828 IPSP_MOUSE (51-420): 5.07e-147: 425: 45.41		TM11E_MOUSE (20-255): 8.7e-102: 304: 31.12
+	Hs
		1218311 SPA12_HUMAN (4-420): 3.8e-149: 431: 34.77		TM11E_HUMAN (25-255): 3.04e-99: 297: 29.66
+	Hs
		420739 KAIN_HUMAN (45-422): 2.27e-143: 416: 46.98		KLK1_HUMAN (5-257): 8.51e-98: 288: 28.73
+	Mm
		1141519 SPB6_MOUSE (49-420): 2.54e-143: 415: 32.98		KLK8_MOUSE (8-253): 2.41e-96: 284: 32.41
+	Hs
		344274 AACT_HUMAN (1-423): 0: 526: 100.00		KLK2_HUMAN (9-250): 2.31e-31: 118: 35.25
+	Hs
		344265 AACT_HUMAN (1-423): 0: 526: 100.00		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07
+	Hs
		344256 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		KLK4_HUMAN (8-256): 4.55e-38: 135: 36.36
+	Hs
		486155 SPB9_HUMAN (48-420): 3.52e-155: 445: 33.42		GRAB_HUMAN (25-255): 4.24e-39: 137: 36.82
+	Hs
		344162 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		PRTN3_HUMAN (25-255): 1.19e-33: 124: 37.24
+	Hs
		344151 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07
+	Hs
		397636 IPSP_HUMAN (51-420): 1.43e-152: 439: 49.46		KLK2_HUMAN (9-250): 2.31e-31: 118: 35.25
+	Hs
		439065 ILEU_HUMAN (48-420): 5.44e-142: 411: 34.12		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07