Interactor 1: ANGT (P01019)
Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]
Gene: AGT

Interactor 2: AGTR2 (P50052)
Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2 receptor)
Gene: AGTR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 0.60 0.595

The method score is based on:

Property Details
Experiments 29967536, 23597562
Identification Methods x-ray crystallography, scintillation proximity assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001974 - blood vessel remodeling
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007199 - G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008217 - regulation of blood pressure
GO:0038060 - nitric oxide-cGMP-mediated signaling
and 4 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 476
Hs

1 363
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024