HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: CR1 (P17927)
Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
Gene: CR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.52 1.00 0.724

The method score is based on:

Property Details
Experiments 2141838
Identification Methods protease assay, pull down
Interaction Type protein cleavage, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms GO:0001970 - positive regulation of activation of membrane attack complex
GO:0002430 - complement receptor mediated signaling pathway
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0006957 - complement activation, alternative pathway
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1663
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Last updated: 15 Jul 2024