HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: FHR5 (Q9BXR6)
Complement factor H-related protein 5 (FHR-5)
Gene: CFHR5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11058592
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006956 - complement activation GO:0006957 - complement activation, alternative pathway GO:0032991 - protein-containing complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1663 Hs			1 569
+	Hs
		344697 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR4_HUMAN (1-569): 2.18e-117: 361: 34.34
+	Hs
		344624 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAH_HUMAN (8-568): 1.1e-56: 208: 20.48
+	Hs
		344662 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR3_HUMAN (265-569): 7.95e-56: 192: 33.86
+	Hs
		344636 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR1_HUMAN (1-319): 8.52e-38: 151: 17.73
+	Hs
		344663 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR1_HUMAN (87-365): 1.68e-37: 143: 23.88
+	Hs
		344638 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR2_HUMAN (319-569): 2.54e-27: 119: 21.93
+	Hs
		344619 CO3_HUMAN (1-1663): 0: 2219: 100.00		F13B_HUMAN (352-569): 3.41e-23: 106: 19.57
+	Hs
		344632 CO3_HUMAN (1-1663): 0: 2219: 100.00		MCP_HUMAN (6-154): 7.08e-11: 66.4: 21.29
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAB_HUMAN (8-160): 1.81e-10: 66: 13.69
+	Rn
		344734 CO3_RAT (24-1663): 0: 2142: 78.18		Q6MG73_RAT (268-464): 6.03e-20: 96: 17.76
+	Mm
		344735 CO3_MOUSE (1-1663): 0: 2139: 76.77		CFAH_MOUSE (437-569): 2.06e-09: 62.5: 18.12
+	Hs
		469908 CO4B_HUMAN (16-1661): 0: 1625: 28.37		FHR4_HUMAN (1-569): 2.18e-117: 361: 34.34
+	Hs
		469878 CO4A_HUMAN (16-1661): 0: 1624: 28.20		FHR4_HUMAN (1-569): 2.18e-117: 361: 34.34
+	Hs
		416130 CO4B_HUMAN (16-1661): 0: 1625: 28.37		CO2_HUMAN (207-383): 1.54e-23: 107: 20.64
+	Hs
		416129 CO4A_HUMAN (16-1661): 0: 1624: 28.20		CO2_HUMAN (207-383): 1.54e-23: 107: 20.64
+	Hs
		344753 CO5_HUMAN (10-1661): 0: 1664: 27.73		CO6_HUMAN (261-387): 8.23e-09: 60.6: 17.56
+	Hs
		469899 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MCP_HUMAN (6-154): 7.08e-11: 66.4: 21.29
+	Hs
		344406 A2MG_HUMAN (19-1498): 0: 1369: 23.02		F13B_HUMAN (352-569): 3.41e-23: 106: 19.57