HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	29467282, 28205554, 28628118
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000165 - MAPK cascade GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 347
+	Hs
		346044 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76
+	Hs
		347148 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MARK2_HUMAN (8-344): 2.1e-119: 364: 20.41
+	Hs
		346663 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		STK4_HUMAN (42-345): 1.62e-103: 314: 33.12
+	Hs
		160313 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		346681 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MP2K5_HUMAN (56-324): 7.89e-66: 216: 45.09
+	Hs
		346568 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MP2K1_HUMAN (49-344): 5.25e-65: 212: 36.69
+	Hs
		379041 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		MARK3_HUMAN (8-344): 6.23e-120: 364: 19.53
+	Hs
		379539 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		MARK2_HUMAN (8-344): 2.1e-119: 364: 20.41
+	At
		1105320 MYC2_ARATH (200-454): 1.78e-32: 132: 18.05		KIN10_ARATH (63-337): 5.54e-124: 367: 23.83
+	Hs
		160320 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		681801 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76
+	Hs
		252905 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		MARK3_HUMAN (8-344): 6.23e-120: 364: 19.53
+	Hs
		160351 MYCL_HUMAN (29-449): 4.2e-42: 154: 30.11		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		160534 SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70