HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 12660246, 26496610, 25609649, 17353931, 12706874, 27859590, 29467282, 16410719, 30415952, 10319872, 12584560, 2006410, 10593926, 32140074, 31767764, 33298911, 35140242, 35013218, 36352191, 36424410 and 47 others

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Identification Methods affinity chromatography technology, pull down, proximity labelling technology, two hybrid, fluorescent resonance energy transfer, x-ray crystallography, coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification, two hybrid array and 5 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH, HLH~Myc-LZ
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 - DNA binding
and 9 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 454
Hs

1 160
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Last updated: 15 Jul 2024