HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36424410, 21150319
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 375
+	Hs
		346966 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		346367 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		346479 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		346482 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ACTS_HUMAN (2-375): 0: 594: 93.85
+	Hs
		379183 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Dm
		862588 MYC_DROME (210-454): 3.25e-30: 126: 26.74		ACT3_DROME (2-375): 0: 596: 94.92