HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	25438055, 19131971, 17632056
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 309
+	Hs
		346104 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PP1G_HUMAN (7-306): 0: 505: 45.96
+	Hs
		346409 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PP1A_HUMAN (5-296): 0: 504: 46.51
+	Hs
		379204 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PP1A_HUMAN (5-296): 0: 504: 46.51
+	Hs
		607790 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		PP1G_HUMAN (7-306): 0: 505: 45.96
+	Hs
		898097 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		PP2AA_HUMAN (1-309): 0: 529: 100.00
+	Hs
		898094 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		PP2AB_HUMAN (1-309): 0: 528: 97.41
+	Mm
		659347 MAX_MOUSE (354-454): 3.52e-25: 102: 32.67		PP1G_MOUSE (7-306): 0: 506: 45.96
+	Mm
		659345 MAX_MOUSE (354-454): 3.52e-25: 102: 32.67		PP1A_MOUSE (5-296): 0: 504: 46.84
+	Hs
		737681 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		PP1G_HUMAN (7-306): 0: 505: 45.96
+	Hs
		898092 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		PP1A_HUMAN (5-296): 0: 504: 46.51
+	Mm
		659346 MAX_MOUSE (354-454): 3.52e-25: 102: 32.67		PP1B_MOUSE (6-299): 3.71e-179: 499: 44.88